Gérard Chaouat1, Sylvie Dubanchet, Nathalie Ledée. 1. U 782 INSERM, Equipe cytokines et dialogue cytokinique mère conceptus, Université Paris Sud et Hôpîtal Antoine Béclère, 32 rue des Carnets, Clamart Cedex, France. gerard_chaouat@wanadoo.fr
Abstract
PROBLEM: Cytokines are obviously very important in an established pregnancy, but what about human embryo implantation? METHODS: Literature review. RESULTS: We first discuss the necessity and limits of animal models, and then review the few cytokines which have been demonstrated by knock-out methods to be absolutely necessary for embryo implantation using in animal models. We then review what is known or discussed about the role of other cytokines as deduced from quantitative and/or qualitative dysregulation in animals and in humans. CONCLUSIONS: Cytokines are indeed involved in implantation as they are in ongoing pregnancy and delivery. Relevance to infertility and recurrent pregnancy loss is discussed.
PROBLEM: Cytokines are obviously very important in an established pregnancy, but what about human embryo implantation? METHODS: Literature review. RESULTS: We first discuss the necessity and limits of animal models, and then review the few cytokines which have been demonstrated by knock-out methods to be absolutely necessary for embryo implantation using in animal models. We then review what is known or discussed about the role of other cytokines as deduced from quantitative and/or qualitative dysregulation in animals and in humans. CONCLUSIONS: Cytokines are indeed involved in implantation as they are in ongoing pregnancy and delivery. Relevance to infertility and recurrent pregnancy loss is discussed.
Authors: Andréa Albieri; Mara S Hoshida; Sonia M Gagioti; Eduardo C Leanza; Ises Abrahamsohn; Anne Croy; Ali A Ashkar; Estela Bevilacqua Journal: Reprod Biol Endocrinol Date: 2005-08-10 Impact factor: 5.211
Authors: Laura D Almquist; Creighton E Likes; Benjamin Stone; Kaitlin R Brown; Ricardo Savaris; David A Forstein; Paul B Miller; Bruce A Lessey Journal: Fertil Steril Date: 2017-11-07 Impact factor: 7.329
Authors: Koji Yoshinaga; Mercy PrabhuDas; Christopher Davies; Kenneth White; Kathleen Caron; Thaddeus Golos; Asgerally Fazleabas; Bibhash Paria; Gil Mor; Soumen Paul; Xiaoqin Ye; Sudhansu K Dey; Thomas Spencer; Robert Michael Roberts Journal: Am J Reprod Immunol Date: 2013-11-29 Impact factor: 3.886