OBJECTIVES: To assess the tracheal morphologic changes using CT in COPD (chronic obstructive lung disease) patients and to assess correlation between them and PFT (pulmonary function test) and CT parameters. MATERIALS AND METHODS: Ninety-two healthy individuals and 115 patients with COPD who underwent volumetric inspiration/expiration CT scanning were included. The Lsag, Lcor, and the tLA were measured. The TI was defined as the ratio of Lcor/Lsag. The tracheal morphologic changes (tLA, TI, and collapsibility) were compared in healthy individuals and COPD. In COPD patients, correlation of the tracheal morphologic change with PFT and CT parameters was assessed. RESULTS: The TIs in the COPD patients were significantly lower than those in the control group (0.80±0.15 vs. 0.88±0.11, Mean±SD) (p<0.01). In COPD patients, TI correlated with FEV1 (r=0.29, p=<0.01), FEV1/FVC (r=0.26, p<0.01), and the GOLD stage (r=-0.26, p<0.01). TI showed significant correlation with EI on both inspiration and expiration CT (r=-0.19, p=0.04 and r=-0.23, p=0.02), MLD on expiration CT (r=0.27, p<0.01), CT-ATI (r=0.34, p<0.01), and with LV on expiration CT (r=-0.25, p<0.01). CONCLUSION: Among the tracheal morphologic changes, the most significant change in COPD patients compared with that in the control group, was the TI. In COPD patients, the tracheal morphologic change showed clinically significant correlation with severity of emphysema and CT indices.
OBJECTIVES: To assess the tracheal morphologic changes using CT in COPD (chronic obstructive lung disease) patients and to assess correlation between them and PFT (pulmonary function test) and CT parameters. MATERIALS AND METHODS: Ninety-two healthy individuals and 115 patients with COPD who underwent volumetric inspiration/expiration CT scanning were included. The Lsag, Lcor, and the tLA were measured. The TI was defined as the ratio of Lcor/Lsag. The tracheal morphologic changes (tLA, TI, and collapsibility) were compared in healthy individuals and COPD. In COPDpatients, correlation of the tracheal morphologic change with PFT and CT parameters was assessed. RESULTS: The TIs in the COPDpatients were significantly lower than those in the control group (0.80±0.15 vs. 0.88±0.11, Mean±SD) (p<0.01). In COPDpatients, TI correlated with FEV1 (r=0.29, p=<0.01), FEV1/FVC (r=0.26, p<0.01), and the GOLD stage (r=-0.26, p<0.01). TI showed significant correlation with EI on both inspiration and expiration CT (r=-0.19, p=0.04 and r=-0.23, p=0.02), MLD on expiration CT (r=0.27, p<0.01), CT-ATI (r=0.34, p<0.01), and with LV on expiration CT (r=-0.25, p<0.01). CONCLUSION: Among the tracheal morphologic changes, the most significant change in COPDpatients compared with that in the control group, was the TI. In COPDpatients, the tracheal morphologic change showed clinically significant correlation with severity of emphysema and CT indices.
Authors: Leticia Gallardo Estrella; Esther Pompe; Jan-Martin Kuhnigk; David A Lynch; Surya P Bhatt; Bram van Ginneken; Eva Marjolein van Rikxoort Journal: Med Phys Date: 2017-05-22 Impact factor: 4.071
Authors: David A Lynch; John H M Austin; James C Hogg; Philippe A Grenier; Hans-Ulrich Kauczor; Alexander A Bankier; R Graham Barr; Thomas V Colby; Jeffrey R Galvin; Pierre Alain Gevenois; Harvey O Coxson; Eric A Hoffman; John D Newell; Massimo Pistolesi; Edwin K Silverman; James D Crapo Journal: Radiology Date: 2015-05-11 Impact factor: 11.105
Authors: Esther Pompe; Pim A de Jong; Eva M van Rikxoort; Leticia Gallardo Estrella; Werner U de Jong; Rozemarijn Vliegenthart; Matthijs Oudkerk; Carlijn M van der Aalst; Bram van Ginneken; Jan-Willem J Lammers; Firdaus Aa Mohamed Hoesein Journal: Int J Chron Obstruct Pulmon Dis Date: 2016-06-08
Authors: So Young Jeung; Sang June Sohn; Ju Hyun An; Hyung Kyu Chae; Qiang Li; Mincheol Choi; Junghee Yoon; Woo Jin Song; Hwa Young Youn Journal: J Vet Sci Date: 2019-09 Impact factor: 1.672