BACKGROUND: Severe brain injuries may be a risk factor for the development of dementia in later life. Less severe incidents with relatively short or even no loss of consciousness may not carry the same prognosis. OBJECTIVES: This study used data from the first two waves of the Canadian Study of Health and Ageing (CSHA-1 and CSHA-2) to investigate two questions. (1) Does a history of head injury improve the prediction of the diagnosis of dementia? This analysis was based on the 921 elderly individuals who underwent a clinical assessment in CSHA-2 and, 5 years earlier, had reported whether or not they had had a head injury. (2) Does adding information about a history of head injury improve the prediction of neuropsychological test scores? This second analysis included 585 elderly people who underwent neuropsychological assessment in both waves and who also reported whether or not they had had a history of mild or moderate-to-severe head injury. RESULTS: RESULTS showed that the inclusion of head injury information did not improve the prediction of diagnostic outcome of dementia. Age and overall cognitive status were associated with most neuropsychological test scores, more so than the more limited influence of chronic health problems, which was associated with about half of the neuropsychological measures.
BACKGROUND: Severe brain injuries may be a risk factor for the development of dementia in later life. Less severe incidents with relatively short or even no loss of consciousness may not carry the same prognosis. OBJECTIVES: This study used data from the first two waves of the Canadian Study of Health and Ageing (CSHA-1 and CSHA-2) to investigate two questions. (1) Does a history of head injury improve the prediction of the diagnosis of dementia? This analysis was based on the 921 elderly individuals who underwent a clinical assessment in CSHA-2 and, 5 years earlier, had reported whether or not they had had a head injury. (2) Does adding information about a history of head injury improve the prediction of neuropsychological test scores? This second analysis included 585 elderly people who underwent neuropsychological assessment in both waves and who also reported whether or not they had had a history of mild or moderate-to-severe head injury. RESULTS: RESULTS showed that the inclusion of head injury information did not improve the prediction of diagnostic outcome of dementia. Age and overall cognitive status were associated with most neuropsychological test scores, more so than the more limited influence of chronic health problems, which was associated with about half of the neuropsychological measures.
Authors: Christian LoBue; Kristin Wilmoth; C Munro Cullum; Heidi C Rossetti; Laura H Lacritz; Linda S Hynan; John Hart; Kyle B Womack Journal: J Neurol Neurosurg Psychiatry Date: 2015-09-10 Impact factor: 10.154
Authors: E Julia Chosy; Noele Gross; Marnie Meyer; Catherine Y Liu; Steven D Edland; Lenore J Launer; Lon R White Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472
Authors: Christian LoBue; Hannah Wadsworth; Kristin Wilmoth; Matthew Clem; John Hart; Kyle B Womack; Nyaz Didehbani; Laura H Lacritz; Heidi C Rossetti; C Munro Cullum Journal: Clin Neuropsychol Date: 2016-11-18 Impact factor: 3.535
Authors: Deborah E Barnes; Amy L Byers; Raquel C Gardner; Karen H Seal; W John Boscardin; Kristine Yaffe Journal: JAMA Neurol Date: 2018-09-01 Impact factor: 18.302
Authors: Trung P Nguyen; Jeff Schaffert; Christian LoBue; Kyle B Womack; John Hart; C Munro Cullum Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Benjamin L Brett; Raquel C Gardner; Jonathan Godbout; Kristen Dams-O'Connor; C Dirk Keene Journal: Biol Psychiatry Date: 2021-06-02 Impact factor: 13.382