AIMS: To identify and validate homogeneous subtypes of opioid use and related behaviors. DESIGN: Family-based and case-control genetic studies of opioid and/or cocaine dependence. SETTINGS: Clinical and general community samples from Connecticut, Massachusetts, Pennsylvania and South Carolina. PARTICIPANTS: A total of 4061 individuals (2003 individuals from 835 families and 2058 unrelated individuals) recruited to participate in genetic studies. MEASUREMENTS: The computer-assisted Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) was used to assess participants' demographics, medical history, substance use behaviors and disorders and other psychiatric disorders. FINDINGS: Five homogeneous subtypes were identified, which differed on opioid-related measures, demographics and prevalence rates of substance use and psychiatric disorders. Heritability estimates for the two most severely affected subtypes exceeded 0.60. CONCLUSIONS: An empirical approach based on opioid use and related behaviors can yield homogeneous subtypes that could be of value in gene finding for opioid dependence.
AIMS: To identify and validate homogeneous subtypes of opioid use and related behaviors. DESIGN: Family-based and case-control genetic studies of opioid and/or cocaine dependence. SETTINGS: Clinical and general community samples from Connecticut, Massachusetts, Pennsylvania and South Carolina. PARTICIPANTS: A total of 4061 individuals (2003 individuals from 835 families and 2058 unrelated individuals) recruited to participate in genetic studies. MEASUREMENTS: The computer-assisted Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) was used to assess participants' demographics, medical history, substance use behaviors and disorders and other psychiatric disorders. FINDINGS: Five homogeneous subtypes were identified, which differed on opioid-related measures, demographics and prevalence rates of substance use and psychiatric disorders. Heritability estimates for the two most severely affected subtypes exceeded 0.60. CONCLUSIONS: An empirical approach based on opioid use and related behaviors can yield homogeneous subtypes that could be of value in gene finding for opioid dependence.
Authors: Joel Gelernter; Carolien Panhuysen; Roger Weiss; Kathleen Brady; Victor Hesselbrock; Bruce Rounsaville; James Poling; Marsha Wilcox; Lindsay Farrer; Henry R Kranzler Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2005-07-05 Impact factor: 3.568
Authors: Amira Pierucci-Lagha; Joel Gelernter; Grace Chan; Albert Arias; Joseph F Cubells; Lindsay Farrer; Henry R Kranzler Journal: Drug Alcohol Depend Date: 2007-06-27 Impact factor: 4.492
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Authors: Jacob A Beierle; Emily J Yao; Stanley I Goldstein; William B Lynch; Julia L Scotellaro; Anyaa A Shah; Katherine D Sena; Alyssa L Wong; Colton L Linnertz; Olga Averin; David E Moody; Christopher A Reilly; Gary Peltz; Andrew Emili; Martin T Ferris; Camron D Bryant Journal: J Pharmacol Exp Ther Date: 2022-06-10 Impact factor: 4.402
Authors: Genevieve F Dash; Sarah W Feldstein Ewing; Corrin Murphy; Karen A Hudson; Anna C Wilson Journal: Addict Behav Date: 2020-01-11 Impact factor: 3.913
Authors: Kelly E Dunn; Elise M Weerts; Andrew S Huhn; Jennifer R Schroeder; David Andrew Tompkins; George E Bigelow; Eric C Strain Journal: Addict Biol Date: 2018-10-08 Impact factor: 4.280