Literature DB >> 21302964

Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana.

Uraiwan Songsiang1, Tula Thongthoom, Chantana Boonyarat, Chavi Yenjai.   

Abstract

Four new carbazole alkaloids, claurailas A-D (1-4), as well as 12 known carbazoles and three known coumarins were isolated from the roots of Clausena harmandiana. Heptaphylline (6) and 7-methoxyheptaphylline (7) showed strong cytotoxicity against NCI-H187 and KB cell lines with IC(50) values ranging from 1.3 to 2.7 μM. Compound 7 showed no cytotoxicity against Vero cells.

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Year:  2011        PMID： 21302964     DOI： 10.1021/np100654m

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

Review 1.  Synthesis of indole derivatives as prevalent moieties present in selected alkaloids.

Authors:  Majid M Heravi; Zahra Amiri; Kosar Kafshdarzadeh; Vahideh Zadsirjan
Journal:  RSC Adv       Date:  2021-10-15       Impact factor: 4.036

Review 2.  Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.

Authors:  Natalia Guzior; Anna Wieckowska; Dawid Panek; Barbara Malawska
Journal:  Curr Med Chem       Date:  2015       Impact factor: 4.530

3.  Chemical constituents from stem bark and roots of Clausena anisata.

Authors:  Jules Lobe Songue; Etienne Dongo; Theophile Ngando Mpondo; Robert L White
Journal:  Molecules       Date:  2012-11-20       Impact factor: 4.411

4.  Bio-Guided Isolation of Prospective Bioactive Constituents from Roots of Clausena indica (Dalzell) Oliv.

Authors:  Nguyen Van Quan; Tran Dang Xuan; La Hoang Anh; Hoang-Dung Tran
Journal:  Molecules       Date:  2019-12-04       Impact factor: 4.411

5.  Engineered Bacterial Flavin-Dependent Monooxygenases for the Regiospecific Hydroxylation of Polycyclic Phenols.

Authors:  Susann Herrmann; Martin Dippe; Pascal Pecher; Evelyn Funke; Markus Pietzsch; Ludger A Wessjohann
Journal:  Chembiochem       Date:  2022-02-09       Impact factor: 3.461

6.  Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives.

Authors:  Lan-Xiang Liu; Xue-Quan Wang; Bei Zhou; Li-Juan Yang; Yan Li; Hong-Bin Zhang; Xiao-Dong Yang
Journal:  Sci Rep       Date:  2015-08-19       Impact factor: 4.379

7.  Cytotoxicity and Apoptosis Induction of Coumarins and Carbazole Alkaloids from Clausena harmandiana.

Authors:  Porntip Jantamat; Natthida Weerapreeyakul; Ploenthip Puthongking
Journal:  Molecules       Date:  2019-09-18       Impact factor: 4.411

8.  Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.

Authors:  Jing-Hua Yang; Xin-Yi Wang; Yi-Ping Zhou; Rong Lu; Chin-Ho Chen; Meng-Han Zhang; Yung-Yi Cheng; Susan L Morris-Natschke; Kuo-Hsiung Lee; Yun-Song Wang
Journal:  Molecules       Date:  2019-12-26       Impact factor: 4.411
  8 in total

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