Literature DB >> 21301753

In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines.

Manuela Tosin1, Yuliya Demydchuk, James S Parascandolo, Covadonga Blasco Per, Finian J Leeper, Peter F Leadlay.   

Abstract

Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted by malonyl carba(dethia)-N-acetyl cysteamines, generated in vivo from the hydrolysis of the corresponding methyl esters.

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Year:  2011        PMID： 21301753     DOI： 10.1039/c0cc05077f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

1.  Chemical biology: biosynthetic interceptors.

Authors:  Niclas Pryk; Frank Schulz
Journal:  Nat Chem       Date:  2015-02       Impact factor: 24.427

2.  Elucidating the mechanism of fluorinated extender unit loading for improved production of fluorine-containing polyketides.

Authors:  Omer Ad; Benjamin W Thuronyi; Michelle C Y Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-17       Impact factor: 11.205

3.  Nonlinear Biosynthetic Assembly of Alpiniamide by a Hybrid cis/trans-AT PKS-NRPS.

Authors:  Renata Sigrist; Hanna Luhavaya; Shaun M K McKinnie; Amanda Ferreira da Silva; Igor D Jurberg; Bradley S Moore; Luciana Gonzaga de Oliveira
Journal:  ACS Chem Biol       Date:  2020-04-06       Impact factor: 5.100

4.  Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8.

Authors:  Katherine Belecki; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2013-09-17       Impact factor: 15.419

5.  Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates.

Authors:  Zhizeng Gao; Jingjing Wang; Amy K Norquay; Kangjian Qiao; Yi Tang; John C Vederas
Journal:  J Am Chem Soc       Date:  2013-01-28       Impact factor: 15.419

6.  Site-specific modification of the anticancer and antituberculosis polyether salinomycin by biosynthetic engineering.

Authors:  Hanna Luhavaya; Simon R Williams; Hui Hong; Luciana Gonzaga de Oliveira; Peter F Leadlay
Journal:  Chembiochem       Date:  2014-08-22       Impact factor: 3.164

7.  Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains.

Authors:  Yang Li; William D Fiers; Steffen M Bernard; Janet L Smith; Courtney C Aldrich; Robert A Fecik
Journal:  ACS Chem Biol       Date:  2014-11-05       Impact factor: 5.100

8.  Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes.

Authors:  James S Parascandolo; Judith Havemann; Helen K Potter; Fanglu Huang; Elena Riva; Jack Connolly; Ina Wilkening; Lijiang Song; Peter F Leadlay; Manuela Tosin
Journal:  Angew Chem Weinheim Bergstr Ger       Date:  2016-02-02

Review 9.  Second-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assembly.

Authors:  Ina Wilkening; Silvia Gazzola; Elena Riva; James S Parascandolo; Lijiang Song; Manuela Tosin
Journal:  Chem Commun (Camb)       Date:  2016-08-16       Impact factor: 6.222

10.  Chemical probes for the functionalization of polyketide intermediates.

Authors:  Elena Riva; Ina Wilkening; Silvia Gazzola; W M Ariel Li; Luke Smith; Peter F Leadlay; Manuela Tosin
Journal:  Angew Chem Int Ed Engl       Date:  2014-09-11       Impact factor: 15.336
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