| Literature DB >> 21300712 |
Janusz Kaczorowski1, Larry W Chambers, Lisa Dolovich, J Michael Paterson, Tina Karwalajtys, Tracy Gierman, Barbara Farrell, Beatrice McDonough, Lehana Thabane, Karen Tu, Brandon Zagorski, Ron Goeree, Cheryl A Levitt, William Hogg, Stephanie Laryea, Megan Ann Carter, Dana Cross, Rolf J Sabaldt.
Abstract
OBJECTIVE: To evaluate the effectiveness of the community based Cardiovascular Health Awareness Program (CHAP) on morbidity from cardiovascular disease.Entities:
Mesh:
Year: 2011 PMID: 21300712 PMCID: PMC3034422 DOI: 10.1136/bmj.d442
Source DB: PubMed Journal: BMJ ISSN: 0959-8138

Profile of CHAP trial, including main components of intervention. CHAP=Cardiovascular Health Awareness Program
Baseline characteristics of CHAP trial communities (on 1 September 2006). Values are means (SD)
| Control communities (n=19) | Intervention communities (n=20) | |
|---|---|---|
| No of residents aged ≥65 years | 3829.89 (2176.44) | 3393.70 (1831.59) |
| Age (years) | 74.79 (0.43) | 74.82 (0.62) |
| Male sex (%) | 42.65 (1.19) | 42.92 (2.16) |
| Rurality index20 | 28.96 (13.60) | 31.63 (14.09) |
| Low income status (%)* | 16.95 (8.55) | 18.57 (11.33) |
| No of prescription drugs in previous year | 7.25 (0.49) | 6.98 (0.54) |
| No of comorbidity groups in previous 2 years21 | 7.31 (0.30) | 7.17 (0.50) |
| Charlson comorbidity index in previous 2 years22 | 0.57 (0.09) | 0.58 (0.11) |
| Diabetes (%)23 | 22.16 (2.34) | 21.20 (2.79) |
| History of congestive heart failure (%)24 | 12.19 (1.91) | 12.45 (2.34) |
| Death rate per 100 in previous year | 3.45 (0.40) | 3.55 (0.57) |
*Member of lowest fifth of neighbourhood income in 2006 Canadian census.
Comparison of mean hospital admission rates per 1000 by study arm
| Hospital admissions | Pre-intervention rate (1 September 2005 to 31 August 2006) | Post-intervention rate (1 September 2007 to 31 August 2008) | Rate ratio (95% CI); P value | |||
|---|---|---|---|---|---|---|
| CHAP (n=67 874) | Control (n=72 768) | CHAP (n=69 942) | Control (n=75 499) | |||
| Composite | 30.15 | 29.36 | 27.90 | 30.13 | 0.91 (0.86 to 0.97); <0.01 | |
| Acute myocardial infarction | 10.24 | 10.26 | 9.54 | 10.81 | 0.87 (0.79 to 0.97); <0.01 | |
| Congestive heart failure | 11.19 | 11.11 | 10.51 | 12.22 | 0.90 (0.81 to 0.99); 0.03 | |
| Stroke | 8.71 | 7.99 | 7.86 | 7.10 | 0.99 (0.88 to 1.12); 0.89 | |
Comparison of mean number of residents admitted to hospital per 1000 by study arm
| Residents admitted | Pre-intervention rate (1 September 2005 to 31 August 2006) | Post-intervention rate (1 September 2007 to 31 August 2008) | Rate ratio (95% CI); P value | |||
|---|---|---|---|---|---|---|
| CHAP (n=67 874) | Control (n=72 768) | CHAP (n=69 942) | Control (n=75 499) | |||
| Composite | 24.79 | 24.64 | 23.43 | 24.22 | 0.95 (0.89 to 1.02); 0.13 | |
| Acute myocardial infarction | 8.89 | 8.97 | 8.17 | 9.34 | 0.89 (0.79 to 0.99); 0.03 | |
| Congestive heart failure | 9.27 | 9.24 | 8.85 | 9.31 | 0.97 (0.87 to 1.08); 0.59 | |
| Stroke | 7.81 | 7.46 | 7.23 | 6.56 | 1.01 (0.89 to 1.15); 0.87 | |
| In-hospital death from cardiovascular disease | 4.35 | 4.46 | 3.88 | 4.66 | 0.86 (0.73 to 1.01); 0.06 | |
| All cause mortality | 35.45 | 33.13 | 33.98 | 34.55 | 0.98 (0.92 to 1.03); 0.38 | |
| Antihypertensive treatment started | 14.66 | 14.16 | 16.35* | 15.31* | 1.10 (1.02 to 1.20); 0.02 | |
*1 September 2006 to 31 August 2007.