| Literature DB >> 21300100 |
Jennifer Humberd Smith1, Paula Brooks, Scott Johnson, S Mark Tompkins, Koren M Custer, Debra L Haas, Raydel Mair, Mark Papania, Ralph A Tripp.
Abstract
Live-attenuated influenza vaccine (LAIV) delivered by large droplet intranasal spray is efficacious against infection. However, many of the large droplets are trapped in the external nares and do not reach the target nasal airway tissues. Smaller droplets might provide better distribution yielding similar protection with lower doses. We evaluated 20 and 30 μm aerosol delivery of influenza virus in mice. A 15s aerosol exposure optimally protected against homologous and heterologous influenza infection and induced a robust immune response. These results demonstrate the feasibility of nasal vaccination using aerosolized particles, providing a strategy to improve vaccine efficacy and delivery.Entities:
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Year: 2011 PMID： 21300100 PMCID： PMC3076080 DOI： 10.1016/j.vaccine.2011.01.059
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641