Literature DB >> 18324893

Influenza and respiratory syncytial virus in the elderly.

Alex J Elliot1, Douglas M Fleming.   

Abstract

Respiratory infections are one of the leading causes of morbidity and mortality worldwide: influenza and respiratory syncytial virus (RSV) are the predominant pathogens responsible. Annual vaccination and the use of antiviral drugs provides both protection and treatment against influenza, particularly protecting those patients most at risk, including the elderly and individuals with chronic comorbidities. Currently, there are extremely limited options in the protection against RSV infection, making those at-risk patients vulnerable to serious disease, complications and death. This review focuses on recent trends in respiratory illness in the elderly, particularly focusing on the burden of influenza and RSV on hospitalizations and mortality. We discuss the potential benefit of influenza vaccination on these outcomes, including the recent controversial debate over the effectiveness of influenza vaccination.

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Year:  2008        PMID: 18324893     DOI: 10.1586/14760584.7.2.249

Source DB:  PubMed          Journal:  Expert Rev Vaccines        ISSN: 1476-0584            Impact factor:   5.217


  22 in total

1.  Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors.

Authors:  Song Feng; Di Hong; Baoxia Wang; Xiufang Zheng; Kun Miao; Lisha Wang; Hongying Yun; Lu Gao; Shuhai Zhao; Hong C Shen
Journal:  ACS Med Chem Lett       Date:  2015-01-25       Impact factor: 4.345

2.  Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex.

Authors:  Alberto Jiménez-Somarribas; Shuli Mao; Jeong-Joong Yoon; Marco Weisshaar; Robert M Cox; Jose R Marengo; Deborah G Mitchell; Zachary P Morehouse; Dan Yan; Ivan Solis; Dennis C Liotta; Michael G Natchus; Richard K Plemper
Journal:  J Med Chem       Date:  2017-03-13       Impact factor: 7.446

3.  IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease.

Authors:  Bryan C Petersen; Vladislav Dolgachev; Andrew Rasky; Nicholas W Lukacs
Journal:  J Leukoc Biol       Date:  2014-01-09       Impact factor: 4.962

4.  Aerosol vaccination induces robust protective immunity to homologous and heterologous influenza infection in mice.

Authors:  Jennifer Humberd Smith; Paula Brooks; Scott Johnson; S Mark Tompkins; Koren M Custer; Debra L Haas; Raydel Mair; Mark Papania; Ralph A Tripp
Journal:  Vaccine       Date:  2011-02-05       Impact factor: 3.641

5.  Attributable deaths due to influenza: a comparative study of seasonal and pandemic influenza.

Authors:  Monika Redlberger-Fritz; Judith Helene Aberle; Therese Popow-Kraupp; Michael Kundi
Journal:  Eur J Epidemiol       Date:  2012-06-08       Impact factor: 8.082

6.  Cross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors.

Authors:  Dan Yan; Sujin Lee; Vidhi D Thakkar; Ming Luo; Martin L Moore; Richard Karl Plemper
Journal:  Proc Natl Acad Sci U S A       Date:  2014-08-04       Impact factor: 11.205

7.  Replication-Competent Influenza Virus and Respiratory Syncytial Virus Luciferase Reporter Strains Engineered for Co-Infections Identify Antiviral Compounds in Combination Screens.

Authors:  Dan Yan; Marco Weisshaar; Kristen Lamb; Hokyung K Chung; Michael Z Lin; Richard K Plemper
Journal:  Biochemistry       Date:  2015-09-01       Impact factor: 3.162

8.  Intranasal nanoemulsion-based inactivated respiratory syncytial virus vaccines protect against viral challenge in cotton rats.

Authors:  Jessica J O'Konek; Paul E Makidon; Jeffrey J Landers; Zhengyi Cao; Carrie-Anne Malinczak; Jessie Pannu; Jennifer Sun; Vira Bitko; Susan Ciotti; Tarek Hamouda; Zbigniew W Wojcinski; Nicholas W Lukacs; Ali Fattom; James R Baker
Journal:  Hum Vaccin Immunother       Date:  2015       Impact factor: 3.452

9.  An adjuvanted respiratory syncytial virus fusion protein induces protection in aged BALB/c mice.

Authors:  Anu Cherukuri; Kate L Stokes; Kathryn Patton; Howard Kuo; Kaori Sakamoto; Stacie Lambert; Elizabeth Stillman; Martin L Moore; Sujin Lee
Journal:  Immun Ageing       Date:  2012-10-02       Impact factor: 6.400

10.  An improved respiratory syncytial virus neutralization assay based on the detection of green fluorescent protein expression and automated plaque counting.

Authors:  Yvonne van Remmerden; Fang Xu; Mandy van Eldik; Jacco G M Heldens; Willem Huisman; Myra N Widjojoatmodjo
Journal:  Virol J       Date:  2012-10-31       Impact factor: 4.099

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