| Literature DB >> 21300016 |
Mamadou Wélé1, Abdoulaye A Djimdé, Aldiouma Guindo, Abdoul H Beavogui, Isaac Z Traoré, Aboubacar Sadou, Dackouo Blaise, Dapa A Diallo, Thomas E Wellems, Ogobara K Doumbo.
Abstract
We investigated PfCRT 76T mutation in severe and non-severe malaria in Southern Mali. One hundred and ninety three severe malaria cases were each matched against two non-severe malaria cases. Patients with G6PD deficiency and any known hemoglobin abnormality were excluded. PfCRT 76T was present in 60.8% (n=386) non-severe malaria cases and in 77.2% (n=193) severe malaria cases (p<0.0001). In children 5 years or younger, these proportions were 62.9% (n=294) vs. 73.5% (n=147), respectively (p<0.01). PfCRT 76T was therefore associated with malaria severity in this setting of Mali.Entities:
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Year: 2011 PMID： 21300016 PMCID： PMC4792268 DOI： 10.1016/j.actatropica.2011.01.002
Source DB: PubMed Journal: Acta Trop ISSN： 0001-706X Impact factor: 3.112