Literature DB >> 12497979

Chloroquine resistance of Plasmodium falciparum is associated with severity of disease in Nigerian children.

P E Olumese1, O K Amodu, A Björkman, A A Adeyemo, R A Gbadegesin, O Walker.   

Abstract

Chloroquine resistance of Plasmodium falciparum in vitro was significantly higher in isolates from patients with severe malaria than those with uncomplicated disease. This association may be due to either progression of uncomplicated to severe disease following chloroquine failure or increased virulence of chloroquine-resistant parasites. The implication of this for antimalarial treatment policy is discussed.

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Year:  2002        PMID： 12497979     DOI： 10.1016/s0035-9203(02)90378-0

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  3 in total

1.  High frequency of PfCRT 76T in two Malian villages and its prevalence in severe relative to non-severe malaria.

Authors:  Mamadou Wélé; Abdoulaye A Djimdé; Aldiouma Guindo; Abdoul H Beavogui; Isaac Z Traoré; Aboubacar Sadou; Dackouo Blaise; Dapa A Diallo; Thomas E Wellems; Ogobara K Doumbo
Journal:  Acta Trop       Date:  2011-02-12       Impact factor: 3.112

2.  Safety of Artemisinin-Based Combination Therapies in Nigeria: A Cohort Event Monitoring Study.

Authors:  Peter Usman Bassi; Adeline I Osakwe; Ambrose Isah; Comfort Suku; Musa Kalat; Iliya Jalo; Robinson Daniel Wammanda; Chika Ugochukwu; Olubukula Adesina; Eno Etim Nyong; Frank Osungwu; Shanti Pal; Sylvester Chigozie Nwoasu; Magnus Wallberg; David Coulter
Journal:  Drug Saf       Date:  2013-09       Impact factor: 5.606

3.  Early home treatment of childhood fevers with ineffective antimalarials is deleterious in the outcome of severe malaria.

Authors:  Adebola E Orimadegun; Olukemi K Amodu; Peter E Olumese; Olayemi O Omotade
Journal:  Malar J       Date:  2008-07-29       Impact factor: 2.979
  3 in total

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