Hyun-Joo Seol1, Jae-Won Kim, Hai-Joong Kim. 1. Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea.
Abstract
AIMS: The aim of this study was to investigate retinol-binding protein-4 (RBP4) levels in maternal and umbilical cord serum in patients in the third trimester of pregnancy with preeclampsia in comparison to levels in normal pregnant women. METHODS: The RBP4 levels in maternal and umbilical cord serum were measured and compared by enzyme-linked immunosorbent assay in 16 normal pregnant and 16 patients with preeclampsia. RESULTS: Both maternal and umbilical cord serum RBP4 levels were significantly decreased in patients with preeclampsia, as compared to normal pregnant women (maternal serum, median 168.0 μg/mL vs. 202.0 μg/mL, P<0.001; umbilical cord serum, median 147.9 μg/mL vs. 193.0 μg/mL, P<0.001). Preeclampsia was independently related to RBP4 levels of maternal and umbilical cord serum. CONCLUSION: Both maternal and umbilical cord serum RBP4 levels were lower in patients with preeclampsia than in normal pregnant women in the third trimester of pregnancy.
AIMS: The aim of this study was to investigate retinol-binding protein-4 (RBP4) levels in maternal and umbilical cord serum in patients in the third trimester of pregnancy with preeclampsia in comparison to levels in normal pregnant women. METHODS: The RBP4 levels in maternal and umbilical cord serum were measured and compared by enzyme-linked immunosorbent assay in 16 normal pregnant and 16 patients with preeclampsia. RESULTS: Both maternal and umbilical cord serum RBP4 levels were significantly decreased in patients with preeclampsia, as compared to normal pregnant women (maternal serum, median 168.0 μg/mL vs. 202.0 μg/mL, P<0.001; umbilical cord serum, median 147.9 μg/mL vs. 193.0 μg/mL, P<0.001). Preeclampsia was independently related to RBP4 levels of maternal and umbilical cord serum. CONCLUSION: Both maternal and umbilical cord serum RBP4 levels were lower in patients with preeclampsia than in normal pregnant women in the third trimester of pregnancy.
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