Literature DB >> 2129870

Membrane fatty acid composition shows delta-6-desaturase abnormalities in Alzheimer's disease.

T Nakada1, I L Kwee, W G Ellis.   

Abstract

Brain membrane phospholipid fatty acid composition is investigated in Alzheimer's disease using fresh pathologically proven autopsy material. The most striking abnormalities in Alzheimer brains compared to age-matched controls are found in the n - 6 line of polyunsaturated fatty acids (PUFA) showing an elevation of 18:2 (n - 6) associated with a reduction of 20:4 (n - 6) and 22:4 (n - 6). The findings strongly indicate abnormalities in delta 6-desaturation. The decrease in 22:6 (n - 3) also supports delta 6-desaturase abnormalities. Alteration in PUFA desaturation/elongation processes and resultant membrane abnormalities may play a key role in the pathogenesis of Alzheimer's disease.

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Year:  1990        PMID： 2129870     DOI： 10.1097/00001756-199010000-00018

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  12 in total

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5.  Low plasma N-3 fatty acids and dementia in older persons: the InCHIANTI study.

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6.  Expression of an ovine growth hormone transgene in mice increases arachidonic acid in cellular membranes.

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8.  Association of the gene encoding stearoyl-CoA desaturase (SCD) with fatty acid composition in an intercross population between Landrace and Korean native pigs.

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9.  Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder.

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Review 10.  Lower brain and blood nutrient status in Alzheimer's disease: Results from meta-analyses.

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