Literature DB >> 21297635

Substrate-induced remodeling of the active site regulates human HTRA1 activity.

Linda Truebestein1, Annette Tennstaedt, Timon Mönig, Tobias Krojer, Flavia Canellas, Markus Kaiser, Tim Clausen, Michael Ehrmann.   

Abstract

Crystal structures of active and inactive conformations of the human serine protease HTRA1 reveal that substrate binding to the active site is sufficient to stimulate proteolytic activity. HTRA1 attaches to liposomes, digests misfolded proteins into defined fragments and undergoes substrate-mediated oligomer conversion. In contrast to those of other serine proteases, the PDZ domain of HTRA1 is dispensable for activation or lipid attachment, indicative of different underlying mechanistic features.

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Year:  2011        PMID： 21297635     DOI： 10.1038/nsmb.2013

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  19 in total

Review 1.  The HtrA family of proteases: implications for protein composition and cell fate.

Authors:  Tim Clausen; Chris Southan; Michael Ehrmann
Journal:  Mol Cell       Date:  2002-09       Impact factor: 17.970

2.  HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues.

Authors:  Tobias Krojer; Justyna Sawa; Robert Huber; Tim Clausen
Journal:  Nat Struct Mol Biol       Date:  2010-06-27       Impact factor: 15.369

3.  Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress.

Authors:  Hanna Hasselblatt; Robert Kurzbauer; Corinna Wilken; Tobias Krojer; Justyna Sawa; Juliane Kurt; Rebecca Kirk; Sonja Hasenbein; Michael Ehrmann; Tim Clausen
Journal:  Genes Dev       Date:  2007-10-15       Impact factor: 11.361

Review 4.  Emerging roles of serine proteinases in tissue turnover in arthritis.

Authors:  J M Milner; A Patel; A D Rowan
Journal:  Arthritis Rheum       Date:  2008-12

Review 5.  Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold.

Authors:  J J Perona; C S Craik
Journal:  J Biol Chem       Date:  1997-11-28       Impact factor: 5.157

6.  Crystal structure of the protease domain of a heat-shock protein HtrA from Thermotoga maritima.

Authors:  Dong Young Kim; Dong Ryoung Kim; Sung Chul Ha; Neratur K Lokanath; Chang Jun Lee; Hye-Yeon Hwang; Kyeong Kyu Kim
Journal:  J Biol Chem       Date:  2002-11-27       Impact factor: 5.157

7.  Implications of the serine protease HtrA1 in amyloid precursor protein processing.

Authors:  Sandra Grau; Alfonso Baldi; Rossana Bussani; Xiaodan Tian; Raluca Stefanescu; Michael Przybylski; Peter Richards; Simon A Jones; Viji Shridhar; Tim Clausen; Michael Ehrmann
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-26       Impact factor: 11.205

Review 8.  HtrA serine proteases as potential therapeutic targets in cancer.

Authors:  Jeremy Chien; Mara Campioni; Viji Shridhar; Alfonso Baldi
Journal:  Curr Cancer Drug Targets       Date:  2009-06       Impact factor: 3.428

9.  Age-related macular degeneration.

Authors:  Hanna R Coleman; Chi-Chao Chan; Frederick L Ferris; Emily Y Chew
Journal:  Lancet       Date:  2008-11-22       Impact factor: 79.321

10.  Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control.

Authors:  Michael Meltzer; Sonja Hasenbein; Patrick Hauske; Nicolette Kucz; Melisa Merdanovic; Sandra Grau; Alexandra Beil; Dafydd Jones; Tobias Krojer; Tim Clausen; Michael Ehrmann; Markus Kaiser
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336
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  50 in total

1.  The first Greek case of heterozygous cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy: An atypical clinico-radiological presentation.

Authors:  Anastasia Bougea; George Velonakis; Nikolaos Spantideas; Evangelos Anagnostou; George Paraskevas; Elisabeth Kapaki; Evangelia Kararizou
Journal:  Neuroradiol J       Date:  2017-04-12

2.  Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.

Authors:  Annette Tennstaedt; Simon Pöpsel; Linda Truebestein; Patrick Hauske; Anke Brockmann; Nina Schmidt; Inga Irle; Barbara Sacca; Christof M Niemeyer; Roland Brandt; Hanna Ksiezak-Reding; Anca Laura Tirniceriu; Rupert Egensperger; Alfonso Baldi; Leif Dehmelt; Markus Kaiser; Robert Huber; Tim Clausen; Michael Ehrmann
Journal:  J Biol Chem       Date:  2012-04-25       Impact factor: 5.157

3.  Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.

Authors:  Justyna Sawa; Hélène Malet; Tobias Krojer; Flavia Canellas; Michael Ehrmann; Tim Clausen
Journal:  J Biol Chem       Date:  2011-06-17       Impact factor: 5.157

Review 4.  HTRA proteases: regulated proteolysis in protein quality control.

Authors:  Tim Clausen; Markus Kaiser; Robert Huber; Michael Ehrmann
Journal:  Nat Rev Mol Cell Biol       Date:  2011-02-16       Impact factor: 94.444

Review 5.  Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response.

Authors:  Guido Hansen; Rolf Hilgenfeld
Journal:  Cell Mol Life Sci       Date:  2012-07-18       Impact factor: 9.261

Review 6.  New approaches for dissecting protease functions to improve probe development and drug discovery.

Authors:  Edgar Deu; Martijn Verdoes; Matthew Bogyo
Journal:  Nat Struct Mol Biol       Date:  2012-01-05       Impact factor: 15.369

7.  Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy.

Authors:  Sandeep Kumar; Hiroyuki Nakashizuka; Alex Jones; Alyssia Lambert; Xuchen Zhao; Megan Shen; Mackenzie Parker; Shixian Wang; Zachary Berriochoa; Amrita Fnu; Stephanie VanBeuge; Patricia Chévez-Barrios; Mark Tso; Jon Rainier; Yingbin Fu
Journal:  Am J Pathol       Date:  2017-09-21       Impact factor: 4.307

8.  Activation by substoichiometric inhibition.

Authors:  Melisa Merdanovic; Steven G Burston; Anna Laura Schmitz; Steffen Köcher; Stefan Knapp; Tim Clausen; Markus Kaiser; Robert Huber; Michael Ehrmann
Journal:  Proc Natl Acad Sci U S A       Date:  2020-01-06       Impact factor: 11.205

9.  The Chlamydomonas deg1c Mutant Accumulates Proteins Involved in High Light Acclimation.

Authors:  Jasmine Theis; Julia Lang; Benjamin Spaniol; Suzanne Ferté; Justus Niemeyer; Frederik Sommer; David Zimmer; Benedikt Venn; Shima Farazandeh Mehr; Timo Mühlhaus; Francis-André Wollman; Michael Schroda
Journal:  Plant Physiol       Date:  2019-10-11       Impact factor: 8.340

10.  Catalytic mechanism and mode of action of the periplasmic alginate epimerase AlgG.

Authors:  Francis Wolfram; Elena N Kitova; Howard Robinson; Marthe T C Walvoort; Jeroen D C Codée; John S Klassen; P Lynne Howell
Journal:  J Biol Chem       Date:  2014-01-07       Impact factor: 5.157
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