Literature DB >> 212974

Comparison of the development of resistant strains of Type 1 herpes simplex virus to in vitro antiviral activity of 5-iodo-2'-deoxyuridine or ribavirin.

J H Huffman, L B Allen, R W Sidwell.   

Abstract

Exposure of HSV/1 to low concentrations of ribavirin during 4--5 passages does not produce ribavirin-resistant virus. IDU resistance was developed by HSV/1 while it was being passed simultaneously. This resistance was seen to develop in both KB and Vero cells. The IDU-resistant virus is also resistant to ribavirin in KB cells.

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Year:  1977        PMID： 212974      PMCID： PMC7167924          DOI： 10.1111/j.1749-6632.1977.tb21955.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  6 in total

1.  CELL CULTURE STUDIES ON ANTIVIRAL AGENTS. I. ACTION OF CYTOSINE ARABINOSIDE AND SOME COMPARISONS WITH 5-IODO-2-DEOXYURIDINE.

Authors:  D A BUTHALA
Journal:  Proc Soc Exp Biol Med       Date:  1964-01

2.  Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides.

Authors:  J T Witkowski; R K Robins; R W Sidwell; L N Simon
Journal:  J Med Chem       Date:  1972-11       Impact factor: 7.446

3.  Use of disposable micro tissue culture plates for antiviral and interferon induction studies.

Authors:  R W Sidwell; J H Huffman
Journal:  Appl Microbiol       Date:  1971-11

4.  A working hypothesis--virus resistance development as an indicator of specific antiviral activity.

Authors:  E C Herrmann; J A Herrmann
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

5.  Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

Authors:  R W Sidwell; J H Huffman; G P Khare; L B Allen; J T Witkowski; R K Robins
Journal:  Science       Date:  1972-08-25       Impact factor: 47.728

6.  In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses.

Authors:  J H Huffman; R W Sidwell; G P Khare; J T Witkowski; L B Allen; R K Robins
Journal:  Antimicrob Agents Chemother       Date:  1973-02       Impact factor: 5.191
  6 in total
  1 in total

1.  Failure of type 1 herpesvirus to develop resistance to ribavirin.

Authors:  L B Allen; C M Fingal
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191
  1 in total

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