Literature DB >> 21290067

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases.

Huaming Sheng1, Hongbin Sun.   

Abstract

This review (with 335 references cited) is devoted to pentacyclic triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic behavior of naturally occurring pentacyclic triterpenes are described. We also cover the in vivo evidence, mechanistic studies, and clinical significance of pentacyclic triterpenes as multi-target therapeutic agents for the prevention and treatment of metabolic and vascular diseases.

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Year:  2011        PMID： 21290067     DOI： 10.1039/c0np00059k

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  45 in total

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Authors:  C C Veloso; M C Oliveira; V G Rodrigues; C C Oliveira; L P Duarte; M M Teixeira; A V M Ferreira; A C Perez
Journal:  Inflammopharmacology       Date:  2018-05-31       Impact factor: 4.473

Review 2.  Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products.

Authors:  Zachary G Brill; Matthew L Condakes; Chi P Ting; Thomas J Maimone
Journal:  Chem Rev       Date:  2017-03-15       Impact factor: 60.622

3.  Antitumor Activity of Betulinic Acid and Betulin in Canine Cancer Cell Lines.

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Journal:  In Vivo       Date:  2018 Sep-Oct       Impact factor: 2.155

Review 4.  Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence.

Authors:  Muthu K Shanmugam; Xiaoyun Dai; Alan Prem Kumar; Benny K H Tan; Gautam Sethi; Anupam Bishayee
Journal:  Cancer Lett       Date:  2014-01-30       Impact factor: 8.679

Review 5.  Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents.

Authors:  Haijun Chen; Yu Gao; Ailan Wang; Xiaobin Zhou; Yunquan Zheng; Jia Zhou
Journal:  Eur J Med Chem       Date:  2015-01-16       Impact factor: 6.514

Review 6.  Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.

Authors:  Karen T Liby; Michael B Sporn
Journal:  Pharmacol Rev       Date:  2012-09-10       Impact factor: 25.468

7.  Location, Orientation and Aggregation of Bardoxolone-ME, CDDO-ME, in a Complex Phospholipid Bilayer Membrane.

Authors:  Vicente Galiano; José A Encinar; José Villalaín
Journal:  J Membr Biol       Date:  2020-01-21       Impact factor: 1.843

8.  Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation.

Authors:  Myoung Seok Jeong; Ji Hoon Jung; Hyemin Lee; Chang Geun Kim; Sung-Hoon Kim
Journal:  Onco Targets Ther       Date:  2019-10-23       Impact factor: 4.147

Review 9.  Terpenoids' anti-cancer effects: focus on autophagy.

Authors:  Chirine El-Baba; Amro Baassiri; Georges Kiriako; Batoul Dia; Sukayna Fadlallah; Sara Moodad; Nadine Darwiche
Journal:  Apoptosis       Date:  2021-07-16       Impact factor: 4.677

10.  Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate.

Authors:  Raya Soltane; Amani Chrouda; Ahmed Mostafa; Ahmed A Al-Karmalawy; Karim Chouaïb; Abdelwaheb Dhahri; Rami Adel Pashameah; Ahlam Alasiri; Omnia Kutkat; Mahmoud Shehata; Hichem Ben Jannet; Jawhar Gharbi; Mohamed A Ali
Journal:  Pathogens       Date:  2021-05-19
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