Literature DB >> 21289484

Coding region: the neglected post-transcriptional code.

Eun Kyung Lee1, Myriam Gorospe.   

Abstract

The control of mammalian mRNA turnover and translation has been linked almost exclusively to specific cis-elements within the 5'- and 3'-untranslated regions (UTRs) of the mature mRNA. However, instances of regulated turnover and translation via cis-elements within the coding region (CR) of mRNAs are accumulating. Here, we describe the regulation of post-transcriptional fate through trans-binding factors (RNA-binding proteins and microRNAs) that function via CR sequences. We discuss how the CR enriches the post-transcriptional control of gene expression, and predict that new high-throughput technologies will enable a more mainstream study of CR-governed gene regulation.

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Year:  2011        PMID： 21289484      PMCID： PMC3127077          DOI： 10.4161/rna.8.1.13863

Source DB:  PubMed          Journal:  RNA Biol        ISSN： 1547-6286            Impact factor:   4.652


  45 in total

Review 1.  The cap-to-tail guide to mRNA turnover.

Authors:  C J Wilusz; M Wormington; S W Peltz
Journal:  Nat Rev Mol Cell Biol       Date:  2001-04       Impact factor: 94.444

Review 2.  A unified theory of gene expression.

Authors:  George Orphanides; Danny Reinberg
Journal:  Cell       Date:  2002-02-22       Impact factor: 41.582

3.  Plasminogen activator inhibitor type 2 contains mRNA instability elements within exon 4 of the coding region. Sequence homology to coding region instability determinants in other mRNAs.

Authors:  M J Tierney; R L Medcalf
Journal:  J Biol Chem       Date:  2001-01-26       Impact factor: 5.157

4.  Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs.

Authors:  Ashish Lal; Krystyna Mazan-Mamczarz; Tomoko Kawai; Xiaoling Yang; Jennifer L Martindale; Myriam Gorospe
Journal:  EMBO J       Date:  2004-07-15       Impact factor: 11.598

5.  UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.

Authors:  Tsung-Cheng Chang; Akio Yamashita; Chyi-Ying A Chen; Yukiko Yamashita; Wenmiao Zhu; Simon Durdan; Avak Kahvejian; Nahum Sonenberg; Ann-Bin Shyu
Journal:  Genes Dev       Date:  2004-08-15       Impact factor: 11.361

6.  The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors.

Authors:  R Wisdom; W Lee
Journal:  Genes Dev       Date:  1991-02       Impact factor: 11.361

7.  The code within the code: microRNAs target coding regions.

Authors:  Joshua J Forman; Hilary A Coller
Journal:  Cell Cycle       Date:  2010-04-15       Impact factor: 4.534

8.  A coding region determinant of instability regulates levels of manganese superoxide dismutase mRNA.

Authors:  C A Davis; J M Monnier; H S Nick
Journal:  J Biol Chem       Date:  2001-08-06       Impact factor: 5.157

Review 9.  mRNA stability in eukaryotes.

Authors:  P Mitchell; D Tollervey
Journal:  Curr Opin Genet Dev       Date:  2000-04       Impact factor: 5.578

Review 10.  Regulation of mRNA translation by 5'- and 3'-UTR-binding factors.

Authors:  Gavin S Wilkie; Kirsten S Dickson; Nicola K Gray
Journal:  Trends Biochem Sci       Date:  2003-04       Impact factor: 13.807
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  19 in total

Review 1.  MicroRNAs, wild-type and mutant p53: more questions than answers.

Authors:  Matthew Jones; Ashish Lal
Journal:  RNA Biol       Date:  2012-06-01       Impact factor: 4.652

Review 2.  Post-transcriptional regulation in metabolic diseases.

Authors:  Wook Kim; Eun Kyung Lee
Journal:  RNA Biol       Date:  2012-06-01       Impact factor: 4.652

3.  Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth.

Authors:  James V Michael; Jeremy G T Wurtzel; Guang Fen Mao; A Koneti Rao; Mikhail A Kolpakov; Abdelkarim Sabri; Nicholas E Hoffman; Sudarsan Rajan; Dhanendra Tomar; Muniswamy Madesh; Marvin T Nieman; Johnny Yu; Leonard C Edelstein; Jesse W Rowley; Andrew S Weyrich; Lawrence E Goldfinger
Journal:  Blood       Date:  2017-05-12       Impact factor: 22.113

4.  Differential expression of estrogen receptor beta isoforms in prostate cancer through interplay between transcriptional and translational regulation.

Authors:  Ming-Tsung Lee; Bin Ouyang; Shuk-Mei Ho; Yuet-Kin Leung
Journal:  Mol Cell Endocrinol       Date:  2013-06-24       Impact factor: 4.102

5.  miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression.

Authors:  Eun Kyung Lee; Mi Jeong Lee; Kotb Abdelmohsen; Wook Kim; Mihee M Kim; Subramanya Srikantan; Jennifer L Martindale; Emmette R Hutchison; Hyeon Ho Kim; Bernard S Marasa; Roza Selimyan; Josephine M Egan; Steven R Smith; Susan K Fried; Myriam Gorospe
Journal:  Mol Cell Biol       Date:  2010-12-06       Impact factor: 4.272

6.  Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.

Authors:  Lisheng Dai; Chon-Hwa Tsai-Morris; Hisashi Sato; Joaquin Villar; Jung-Hoon Kang; Jiabao Zhang; Maria L Dufau
Journal:  J Biol Chem       Date:  2011-11-15       Impact factor: 5.157

Review 7.  The fate of the messenger is pre-determined: a new model for regulation of gene expression.

Authors:  Gal Haimovich; Mordechai Choder; Robert H Singer; Tatjana Trcek
Journal:  Biochim Biophys Acta       Date:  2013-01-19

8.  Enhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs.

Authors:  Kotb Abdelmohsen; Kumiko Tominaga; Eun Kyung Lee; Subramanya Srikantan; Min-Ju Kang; Mihee M Kim; Roza Selimyan; Jennifer L Martindale; Xiaoling Yang; France Carrier; Ming Zhan; Kevin G Becker; Myriam Gorospe
Journal:  Nucleic Acids Res       Date:  2011-07-06       Impact factor: 16.971

9.  Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis.

Authors:  Jacob B Spangler; Frank Alex Feltus
Journal:  Front Plant Sci       Date:  2013-05-10       Impact factor: 5.753

10.  RNA-binding protein AUF1 represses Dicer expression.

Authors:  Kotb Abdelmohsen; Kumiko Tominaga-Yamanaka; Subramanya Srikantan; Je-Hyun Yoon; Min-Ju Kang; Myriam Gorospe
Journal:  Nucleic Acids Res       Date:  2012-10-11       Impact factor: 16.971
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