Literature DB >> 2128889

Dereplication of phorbol bioactives: Lyngbya majuscula and Croton cuneatus.

J A Beutler1, A B Alvarado, D E Schaufelberger, P Andrews, T G McCloud.   

Abstract

Lyngbya majuscula and Croton cuneatus were used as prototypes for the dereplication of phorbol ester receptor binding activity using a combination of hplc-uv and online phorbol dibutyrate (PDBu) receptor binding and batch fractionation over either Si gel or diolbonded Si gel. Debromoaplysiatoxin was responsible for the bioactivity of Lyngbya, whereas a complex of potent phorbol esters was detected in C. cuneatus.

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Year:  1990        PMID： 2128889     DOI： 10.1021/np50070a014

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

Review 1.  Current status and contemporary approaches to the discovery of antitumor agents from higher plants.

Authors:  Garima Agarwal; Peter J Blanco Carcache; Ermias Mekuria Addo; A Douglas Kinghorn
Journal:  Biotechnol Adv       Date:  2019-01-08       Impact factor: 14.227

2.  Targeted natural products discovery from marine cyanobacteria using combined phylogenetic and mass spectrometric evaluation.

Authors:  Lilibeth A Salvador-Reyes; Niclas Engene; Valerie J Paul; Hendrik Luesch
Journal:  J Nat Prod       Date:  2015-01-30       Impact factor: 4.050

3.  Natural Products as a Foundation for Drug Discovery.

Authors:  John A Beutler
Journal:  Curr Protoc Pharmacol       Date:  2009-09-01

4.  Comparative study of chromatographic medium-associated mass and potential antitumor activity loss with bioactive extracts.

Authors:  Sandipan Datta; Yu-Dong Zhou; Dale G Nagle
Journal:  J Nat Prod       Date:  2013-02-26       Impact factor: 4.050

Review 5.  Natural Products as a Foundation for Drug Discovery.

Authors:  John A Beutler
Journal:  Curr Protoc Pharmacol       Date:  2019-09

Review 6.  Concepts and Methods to Access Novel Antibiotics from Actinomycetes.

Authors:  Joachim J Hug; Chantal D Bader; Maja Remškar; Katarina Cirnski; Rolf Müller
Journal:  Antibiotics (Basel)       Date:  2018-05-22

7.  1H NMR-MS-based heterocovariance as a drug discovery tool for fishing bioactive compounds out of a complex mixture of structural analogues.

Authors:  Ulrike Grienke; Paul A Foster; Julia Zwirchmayr; Ammar Tahir; Judith M Rollinger; Emmanuel Mikros
Journal:  Sci Rep       Date:  2019-07-31       Impact factor: 4.379

8.  Planomonospora: A Metabolomics Perspective on an Underexplored Actinobacteria Genus.

Authors:  Mitja M Zdouc; Marianna Iorio; Sonia I Maffioli; Max Crüsemann; Stefano Donadio; Margherita Sosio
Journal:  J Nat Prod       Date:  2021-01-26       Impact factor: 4.050

9.  Dereplication of Natural Extracts Diluted in Glycerin: Physical Suppression of Glycerin by Centrifugal Partition Chromatography Combined with Presaturation of Solvent Signals in 13C-Nuclear Magnetic Resonance Spectroscopy.

Authors:  Marine Canton; Jane Hubert; Stéphane Poigny; Richard Roe; Yves Brunel; Jean-Marc Nuzillard; Jean-Hugues Renault
Journal:  Molecules       Date:  2020-10-31       Impact factor: 4.411
  9 in total

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