CONTEXT: The validity of urinary correction standards has not been established for most analytes. METHODS: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. RESULTS: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P < 0.01). There were no differences in model fit between CR- and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P < 0.01). CONCLUSION: CR and SG are valid and interchangeable correction standards.
CONTEXT: The validity of urinary correction standards has not been established for most analytes. METHODS: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. RESULTS: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P < 0.01). There were no differences in model fit between CR- and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P < 0.01). CONCLUSION:CR and SG are valid and interchangeable correction standards.
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