BACKGROUND: IL-1 receptor-like 1 (IL1RL1) is a membrane receptor involved in T(H)2 inflammatory responses and eosinophilia. Single nucleotide polymorphisms (SNPs) in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. OBJECTIVE: We assessed in the prospective birth cohort Prevention and Incidence of Asthma and Mite Allergy (PIAMA) whether IL1RL1 SNPs associate with levels of its soluble transcript IL1RL1 (IL1RL1-a) in serum, blood eosinophil counts, and asthma prevalence from birth to age 8 years, and whether IL1RL1-a serum levels associate with blood eosinophil counts. METHODS: Fifteen IL1RL1 SNPs were genotyped. Serum IL1RL1-a levels were measured in 2 independent subsets within PIAMA, at 4 and 8 years. Blood eosinophil counts were measured in 4-year-old children. RESULTS: In 2 independent subsets of children, 13 of 15 SNPs were associated with serum IL1RL1-a levels at ages 4 and 8 years with a consistent direction of effect for each allele. Rs11685480 allele A and rs1420102 allele A were significantly associated with lower numbers of blood eosinophils. In the total cohort, rs1041973 allele A was associated with a decreased risk of developing asthma (odds ratio, 0.70; 95% CI, 0.54-0.90). Rs1420101, recently identified in a genome-wide association study in the Icelandic population, was not associated with asthma in this study. IL1RL1-a levels were not associated with eosinophil counts. CONCLUSION: We demonstrate that IL1RL1 polymorphisms are associated with serum IL1RL1-a, blood eosinophils, and asthma in childhood.
BACKGROUND: IL-1 receptor-like 1 (IL1RL1) is a membrane receptor involved in T(H)2 inflammatory responses and eosinophilia. Single nucleotide polymorphisms (SNPs) in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. OBJECTIVE: We assessed in the prospective birth cohort Prevention and Incidence of Asthma and Mite Allergy (PIAMA) whether IL1RL1 SNPs associate with levels of its soluble transcript IL1RL1 (IL1RL1-a) in serum, blood eosinophil counts, and asthma prevalence from birth to age 8 years, and whether IL1RL1-a serum levels associate with blood eosinophil counts. METHODS: Fifteen IL1RL1 SNPs were genotyped. Serum IL1RL1-a levels were measured in 2 independent subsets within PIAMA, at 4 and 8 years. Blood eosinophil counts were measured in 4-year-old children. RESULTS: In 2 independent subsets of children, 13 of 15 SNPs were associated with serum IL1RL1-a levels at ages 4 and 8 years with a consistent direction of effect for each allele. Rs11685480 allele A and rs1420102 allele A were significantly associated with lower numbers of blood eosinophils. In the total cohort, rs1041973 allele A was associated with a decreased risk of developing asthma (odds ratio, 0.70; 95% CI, 0.54-0.90). Rs1420101, recently identified in a genome-wide association study in the Icelandic population, was not associated with asthma in this study. IL1RL1-a levels were not associated with eosinophil counts. CONCLUSION: We demonstrate that IL1RL1 polymorphisms are associated with serum IL1RL1-a, blood eosinophils, and asthma in childhood.
Authors: Berran Yucesoy; Michael L Kashon; Victor J Johnson; Zana L Lummus; Kara Fluharty; Denyse Gautrin; André Cartier; Louis-Philippe Boulet; Joaquin Sastre; Santiago Quirce; Susan M Tarlo; Maria-Jesus Cruz; Xavier Munoz; Michael I Luster; David I Bernstein Journal: J Immunotoxicol Date: 2015-09-04 Impact factor: 3.000
Authors: Xin Long; Michelle Daya; Jianping Zhao; Nicholas Rafaels; Huifang Liang; Joseph Potee; Monica Campbell; Bixiang Zhang; Maria Ilma Araujo; Ricardo R Oliveira; Rasika A Mathias; Li Gao; Ingo Ruczinski; Steve N Georas; Donata Vercelli; Terri H Beaty; Kathleen C Barnes; Xiaoping Chen; Qian Chen Journal: J Allergy Clin Immunol Date: 2017-02-09 Impact factor: 10.793
Authors: Erin D Gordon; Joe Palandra; Agata Wesolowska-Andersen; Lando Ringel; Cydney L Rios; Marrah E Lachowicz-Scroggins; Louis Z Sharp; Jamie L Everman; Hannah J MacLeod; Jae W Lee; Robert J Mason; Michael A Matthay; Richard T Sheldon; Michael C Peters; Karl H Nocka; John V Fahy; Max A Seibold Journal: JCI Insight Date: 2016-09-08
Authors: Klaus Bønnelykke; Melanie C Matheson; Tune H Pers; Raquel Granell; David P Strachan; Alexessander Couto Alves; Allan Linneberg; John A Curtin; Nicole M Warrington; Marie Standl; Marjan Kerkhof; Ingileif Jonsdottir; Blazenka K Bukvic; Marika Kaakinen; Patrick Sleimann; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Katharina Schramm; Svetlana Baltic; Eskil Kreiner-Møller; Angela Simpson; Beate St Pourcain; Lachlan Coin; Jennie Hui; Eugene H Walters; Carla M T Tiesler; David L Duffy; Graham Jones; Susan M Ring; Wendy L McArdle; Loren Price; Colin F Robertson; Juha Pekkanen; Clara S Tang; Elisabeth Thiering; Grant W Montgomery; Anna-Liisa Hartikainen; Shyamali C Dharmage; Lise L Husemoen; Christian Herder; John P Kemp; Paul Elliot; Alan James; Melanie Waldenberger; Michael J Abramson; Benjamin P Fairfax; Julian C Knight; Ramneek Gupta; Philip J Thompson; Patrick Holt; Peter Sly; Joel N Hirschhorn; Mario Blekic; Stephan Weidinger; Hakon Hakonarsson; Kari Stefansson; Joachim Heinrich; Dirkje S Postma; Adnan Custovic; Craig E Pennell; Marjo-Riitta Jarvelin; Gerard H Koppelman; Nicholas Timpson; Manuel A Ferreira; Hans Bisgaard; A John Henderson Journal: Nat Genet Date: 2013-06-30 Impact factor: 38.330