Literature DB >> 21278831

Neuropharmacology of Sleep and Wakefulness.

Christopher J Watson1, Helen A Baghdoyan, Ralph Lydic.   

Abstract

The development of sedative/hypnotic molecules has been empiric rather than rational. The empiric approach has produced clinically useful drugs but for no drug is the mechanism of action completely understood. All available sedative/hypnotic medications have unwanted side effects and none of these medications creates a sleep architecture that is identical to the architecture of naturally occurring sleep. This chapter reviews recent advances in research aiming to elucidate the neurochemical mechanisms regulating sleep and wakefulness. One promise of rational drug design is that understanding the mechanisms of sedative/hypnotic action will significantly enhance drug safety and efficacy.

Entities:  

Year:  2010        PMID： 21278831      PMCID： PMC3026477          DOI： 10.1016/j.jsmc.2010.08.003

Source DB:  PubMed          Journal:  Sleep Med Clin        ISSN： 1556-407X


  180 in total

1.  Orexins (hypocretins) directly excite tuberomammillary neurons.

Authors:  L Bayer; E Eggermann; M Serafin; B Saint-Mleux; D Machard; B Jones; M Mühlethaler
Journal:  Eur J Neurosci       Date:  2001-11       Impact factor: 3.386

2.  Effects of lateral preoptic area application of orexin-A on sleep-wakefulness.

Authors:  M M Methippara; M N Alam; R Szymusiak; D McGinty
Journal:  Neuroreport       Date:  2000-11-09       Impact factor: 1.837

Review 3.  5-HT receptor regulation of neurotransmitter release.

Authors:  Klaus B Fink; Manfred Göthert
Journal:  Pharmacol Rev       Date:  2007-12       Impact factor: 25.468

4.  Excitation of the pedunculopontine tegmental NMDA receptors induces wakefulness and cortical activation in the rat.

Authors:  S Datta; E H Patterson; E E Spoley
Journal:  J Neurosci Res       Date:  2001-10-01       Impact factor: 4.164

5.  Dopaminergic role in stimulant-induced wakefulness.

Authors:  J P Wisor; S Nishino; I Sora; G H Uhl; E Mignot; D M Edgar
Journal:  J Neurosci       Date:  2001-03-01       Impact factor: 6.167

6.  GABA(A) receptors in the pontine reticular formation of C57BL/6J mouse modulate neurochemical, electrographic, and behavioral phenotypes of wakefulness.

Authors:  RaShonda R Flint; Theresa Chang; Ralph Lydic; Helen A Baghdoyan
Journal:  J Neurosci       Date:  2010-09-15       Impact factor: 6.167

7.  Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect.

Authors:  Zhong-Wu Liu; Xiao-Bing Gao
Journal:  J Neurophysiol       Date:  2006-11-08       Impact factor: 2.714

8.  Caffeine reduces low-frequency delta activity in the human sleep EEG.

Authors:  H P Landolt; D J Dijk; S E Gaus; A A Borbély
Journal:  Neuropsychopharmacology       Date:  1995-05       Impact factor: 7.853

9.  Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia.

Authors:  Giancarlo Vanini; Christopher J Watson; Ralph Lydic; Helen A Baghdoyan
Journal:  Anesthesiology       Date:  2008-12       Impact factor: 7.892

10.  Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.

Authors:  Shahrad Taheri; Ling Lin; Diane Austin; Terry Young; Emmanuel Mignot
Journal:  PLoS Med       Date:  2004-12-07       Impact factor: 11.069
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  19 in total

Review 1.  Drug-induced sleep: theoretical and practical considerations.

Authors:  Jeffrey M Ellenbogen; Edward F Pace-Schott
Journal:  Pflugers Arch       Date:  2011-09-28       Impact factor: 3.657

2.  Olanzapine causes a leptin-dependent increase in acetylcholine release in mouse prefrontal cortex.

Authors:  Asheley B Wathen; Emily S West; Ralph Lydic; Helen A Baghdoyan
Journal:  Sleep       Date:  2012-03-01       Impact factor: 5.849

3.  Neuropharmacology of Sleep and Wakefulness: 2012 Update.

Authors:  Christopher J Watson; Helen A Baghdoyan; Ralph Lydic
Journal:  Sleep Med Clin       Date:  2012-09-04

Review 4.  Insomnia: the Sleeping Giant of Pediatric Public Health.

Authors:  Emily Badin; Cynthia Haddad; Jess Parker Shatkin
Journal:  Curr Psychiatry Rep       Date:  2016-05       Impact factor: 5.285

5.  Modeling resting-state functional networks when the cortex falls asleep: local and global changes.

Authors:  Gustavo Deco; Patric Hagmann; Anthony G Hudetz; Giulio Tononi
Journal:  Cereb Cortex       Date:  2013-07-10       Impact factor: 5.357

6.  Intranasal Allopregnanolone Confers Rapid Seizure Protection: Evidence for Direct Nose-to-Brain Delivery.

Authors:  Dorota Zolkowska; Chun-Yi Wu; Michael A Rogawski
Journal:  Neurotherapeutics       Date:  2021-01-06       Impact factor: 7.620

7.  Sleep-Dependent Synaptic Down-Selection (II): Single-Neuron Level Benefits for Matching, Selectivity, and Specificity.

Authors:  Atif Hashmi; Andrew Nere; Giulio Tononi
Journal:  Front Neurol       Date:  2013-10-04       Impact factor: 4.003

8.  Molecular Regulation of Betulinic Acid on α3β4 Nicotinic Acetylcholine Receptors.

Authors:  Shinhui Lee; Woog Jung; Sanung Eom; Hye Duck Yeom; Heui-Dong Park; Junho H Lee
Journal:  Molecules       Date:  2021-05-01       Impact factor: 4.411

9.  Sleep-dependent synaptic down-selection (I): modeling the benefits of sleep on memory consolidation and integration.

Authors:  Andrew Nere; Atif Hashmi; Chiara Cirelli; Giulio Tononi
Journal:  Front Neurol       Date:  2013-09-30       Impact factor: 4.003

10.  Leukocyte Expression of Type 1 and Type 2 Purinergic Receptors and Pro-Inflammatory Cytokines during Total Sleep Deprivation and/or Sleep Extension in Healthy Subjects.

Authors:  Mounir Chennaoui; Pierrick J Arnal; Catherine Drogou; Damien Leger; Fabien Sauvet; Danielle Gomez-Merino
Journal:  Front Neurosci       Date:  2017-05-02       Impact factor: 4.677
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