Literature DB >> 23162386

Neuropharmacology of Sleep and Wakefulness: 2012 Update.

Christopher J Watson1, Helen A Baghdoyan, Ralph Lydic.   

Abstract

The development of sedative/hypnotic molecules has been empiric rather than rational. The empiric approach has produced clinically useful drugs but for no drug is the mechanism of action completely understood. All available sedative/hypnotic medications have unwanted side effects and none of these medications creates a sleep architecture that is identical to the architecture of naturally occurring sleep. This chapter reviews recent advances in research aiming to elucidate the neurochemical mechanisms regulating sleep and wakefulness. One promise of rational drug design is that understanding the mechanisms of sedative/hypnotic action will significantly enhance drug safety and efficacy.

Entities:  

Year:  2012        PMID： 23162386      PMCID： PMC3496285          DOI： 10.1016/j.jsmc.2012.06.010

Source DB:  PubMed          Journal:  Sleep Med Clin        ISSN： 1556-407X


  206 in total

1.  Orexins (hypocretins) directly excite tuberomammillary neurons.

Authors:  L Bayer; E Eggermann; M Serafin; B Saint-Mleux; D Machard; B Jones; M Mühlethaler
Journal:  Eur J Neurosci       Date:  2001-11       Impact factor: 3.386

2.  Effects of lateral preoptic area application of orexin-A on sleep-wakefulness.

Authors:  M M Methippara; M N Alam; R Szymusiak; D McGinty
Journal:  Neuroreport       Date:  2000-11-09       Impact factor: 1.837

Review 3.  Histamine H3 receptors and sleep-wake regulation.

Authors:  Jian-Sheng Lin; Olga A Sergeeva; Helmut L Haas
Journal:  J Pharmacol Exp Ther       Date:  2010-09-23       Impact factor: 4.030

Review 4.  5-HT receptor regulation of neurotransmitter release.

Authors:  Klaus B Fink; Manfred Göthert
Journal:  Pharmacol Rev       Date:  2007-12       Impact factor: 25.468

5.  Excitation of the pedunculopontine tegmental NMDA receptors induces wakefulness and cortical activation in the rat.

Authors:  S Datta; E H Patterson; E E Spoley
Journal:  J Neurosci Res       Date:  2001-10-01       Impact factor: 4.164

6.  Dopaminergic role in stimulant-induced wakefulness.

Authors:  J P Wisor; S Nishino; I Sora; G H Uhl; E Mignot; D M Edgar
Journal:  J Neurosci       Date:  2001-03-01       Impact factor: 6.167

7.  GABA(A) receptors in the pontine reticular formation of C57BL/6J mouse modulate neurochemical, electrographic, and behavioral phenotypes of wakefulness.

Authors:  RaShonda R Flint; Theresa Chang; Ralph Lydic; Helen A Baghdoyan
Journal:  J Neurosci       Date:  2010-09-15       Impact factor: 6.167

8.  Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect.

Authors:  Zhong-Wu Liu; Xiao-Bing Gao
Journal:  J Neurophysiol       Date:  2006-11-08       Impact factor: 2.714

9.  Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia.

Authors:  Giancarlo Vanini; Christopher J Watson; Ralph Lydic; Helen A Baghdoyan
Journal:  Anesthesiology       Date:  2008-12       Impact factor: 7.892

10.  Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.

Authors:  Shahrad Taheri; Ling Lin; Diane Austin; Terry Young; Emmanuel Mignot
Journal:  PLoS Med       Date:  2004-12-07       Impact factor: 11.069
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  7 in total

1.  Variations in loop gain and arousal threshold during NREM sleep are affected by time of day over a 24-hour period in participants with obstructive sleep apnea.

Authors:  Shipra Puri; Mohamad El-Chami; David Shaheen; Blake Ivers; Gino S Panza; M Safwan Badr; Ho-Sheng Lin; Jason H Mateika
Journal:  J Appl Physiol (1985)       Date:  2020-08-13

Review 2.  Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders.

Authors:  Milind V Masule; Sumit Rathod; Yogeeta Agrawal; Chandragouda R Patil; Kartik T Nakhate; Shreesh Ojha; Sameer N Goyal; Umesh B Mahajan
Journal:  Curr Res Pharmacol Drug Discov       Date:  2022-06-13

3.  Dynamical Mechanism Underlying Scale-Free Network Reorganization in Low Acetylcholine States Corresponding to Slow Wave Sleep.

Authors:  Paulina Czarnecki; Jack Lin; Sara J Aton; Michal Zochowski
Journal:  Front Netw Physiol       Date:  2021-10-25

4.  Effects of interface pressure distribution on human sleep quality.

Authors:  Zongyong Chen; Yuqian Li; Rong Liu; Dong Gao; Quanhui Chen; Zhian Hu; Jiajun Guo
Journal:  PLoS One       Date:  2014-06-12       Impact factor: 3.240

5.  Depression of Non-Neuronal Cholinergic System May Play a Role in Co-Occurrence of Subjective Daytime Sleepiness and Hypertension in Patients with Obstructive Sleep Apnea Syndrome.

Authors:  Zili Meng; Bing Sun; Wei Chen; Xilong Zhang; Mao Huang; Jing Xu
Journal:  Nat Sci Sleep       Date:  2021-12-14

6.  Mobile Heart Rate Variability Biofeedback Improves Autonomic Activation and Subjective Sleep Quality of Healthy Adults - A Pilot Study.

Authors:  Benedict Herhaus; Adrian Kalin; Haralampos Gouveris; Katja Petrowski
Journal:  Front Physiol       Date:  2022-02-17       Impact factor: 4.566

7.  Association of sleep among 30 antidepressants: a population-wide adverse drug reaction study, 2004-2019.

Authors:  Andy R Eugene
Journal:  PeerJ       Date:  2020-03-11       Impact factor: 2.984
  7 in total

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