| Literature DB >> 21278749 |
Hyun Jung Lee1, Jiae Park1, Ok Ja Yoon2, Hyun Woo Kim2, Do Yeon Lee1, Do Hee Kim1, Won Bok Lee1, Nae-Eung Lee2, Joseph V Bonventre3, Sung Su Kim1.
Abstract
Stroke results in the disruption of tissue architecture and is the third leading cause of death in the United States. Transplanting scaffolds containing stem cells into the injured areas of the brain has been proposed as a treatment strategy, and carbon nanotubes show promise in this regard, with positive outcomes when used as scaffolds in neural cells and brain tissues. Here, we show that pretreating rats with amine-modified single-walled carbon nanotubes can protect neurons and enhance the recovery of behavioural functions in rats with induced stroke. Treated rats showed less tissue damage than controls and took longer to fall from a rotating rod, suggesting better motor functions after injury. Low levels of apoptotic, angiogenic and inflammation markers indicated that amine-modified single-walled carbon nanotubes protected the brains of treated rats from ischaemic injury.Entities:
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Year: 2011 PMID： 21278749 PMCID： PMC4113082 DOI： 10.1038/nnano.2010.281
Source DB: PubMed Journal: Nat Nanotechnol ISSN： 1748-3387 Impact factor: 39.213