| Literature DB >> 26974957 |
Xue Xue1, Jing-Yu Yang2, Yi He3, Li-Rong Wang1,4, Ping Liu2, Li-Sha Yu2, Guo-Hua Bi3, Ming-Ming Zhu2, Yue-Yang Liu2, Rong-Wu Xiang5, Xiao-Ting Yang2, Xin-Yu Fan2, Xiao-Min Wang2, Jia Qi3, Hong-Jie Zhang6, Tuo Wei1,7, Wei Cui2, Guang-Lu Ge1,4, Zheng-Xiong Xi3, Chun-Fu Wu2, Xing-Jie Liang1,7.
Abstract
Methamphetamine (METH) abuse is a serious social and health problem worldwide. At present, there are no effective medications to treat METH addiction. Here, we report that aggregated single-walled carbon nanotubes (aSWNTs) significantly inhibited METH self-administration, METH-induced conditioned place preference and METH- or cue-induced relapse to drug-seeking behaviour in mice. The use of aSWNTs alone did not significantly alter the mesolimbic dopamine system, whereas pretreatment with aSWNTs attenuated METH-induced increases in extracellular dopamine in the ventral striatum. Electrochemical assays suggest that aSWNTs facilitated dopamine oxidation. In addition, aSWNTs attenuated METH-induced increases in tyrosine hydroxylase or synaptic protein expression. These findings suggest that aSWNTs may have therapeutic effects for treatment of METH addiction by oxidation of METH-enhanced extracellular dopamine in the striatum.Entities:
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Year: 2016 PMID： 26974957 PMCID： PMC5535299 DOI： 10.1038/nnano.2016.23
Source DB: PubMed Journal: Nat Nanotechnol ISSN： 1748-3387 Impact factor: 39.213