Literature DB >> 3002633

Role of a ras homolog in the life cycle of Schizosaccharomyces pombe.

Y Fukui, T Kozasa, Y Kaziro, T Takeda, M Yamamoto.   

Abstract

We have analyzed the function of the only ras homolog in S. pombe detectable by Southern blotting, ras1, which is homologous to mammalian ras genes and has been cloned. We have disrupted the ras1 gene and have replaced it with ras1Val17, which corresponds to a transforming variant of mammalian ras. Loss of ras1 activity by disruption results in the complete inability to mate. The cell body of a ras1- strain is extensively deformed, and a ras1-/ras1- diploid sporulates very poorly. Unlike RAS1 and RAS2 of S. cerevisiae, ras1 of S. pombe appears to have no effect on adenylate cyclase activity. This suggests that the target enzymes presumably modulated by ras proteins in signal transduction are not the same for all organisms.

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Year:  1986        PMID： 3002633     DOI： 10.1016/0092-8674(86)90767-1

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  109 in total

1.  Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.

Authors:  K E Mach; K A Furge; C F Albright
Journal:  Genetics       Date:  2000-06       Impact factor: 4.562

2.  Schizosaccharomyces pombe sxa1+ and sxa2+ encode putative proteases involved in the mating response.

Authors:  Y Imai; M Yamamoto
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

3.  byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.

Authors:  Y Wang; H P Xu; M Riggs; L Rodgers; M Wigler
Journal:  Mol Cell Biol       Date:  1991-07       Impact factor: 4.272

4.  Identification of a GTPase-activating protein homolog in Schizosaccharomyces pombe.

Authors:  Y Imai; S Miyake; D A Hughes; M Yamamoto
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

5.  Compartmentalized signaling of Ras in fission yeast.

Authors:  Brian Onken; Heidi Wiener; Mark R Philips; Eric C Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-05       Impact factor: 11.205

Review 6.  Except in every detail: comparing and contrasting G-protein signaling in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Authors:  Charles S Hoffman
Journal:  Eukaryot Cell       Date:  2005-03

7.  Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway.

Authors:  F Douglas Ivey; Charles S Hoffman
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-14       Impact factor: 11.205

8.  Gef1p and Scd1p, the Two GDP-GTP exchange factors for Cdc42p, form a ring structure that shrinks during cytokinesis in Schizosaccharomyces pombe.

Authors:  Kouji Hirota; Kayoko Tanaka; Kunihiro Ohta; Masayuki Yamamoto
Journal:  Mol Biol Cell       Date:  2003-05-29       Impact factor: 4.138

9.  Sexual reproduction as a response to H2O2 damage in Schizosaccharomyces pombe.

Authors:  C Bernstein; V Johns
Journal:  J Bacteriol       Date:  1989-04       Impact factor: 3.490

10.  Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.

Authors:  S Marcus; A Polverino; E Chang; D Robbins; M H Cobb; M H Wigler
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205
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