PURPOSE: To evaluate variability in the definition of preoperative radiotherapy gross tumor volume (GTV) and clinical target volume (CTV) delineated by sarcoma radiation oncologists. METHODS AND MATERIALS: Extremity sarcoma planning CT images along with the corresponding diagnostic MRI from two patients were distributed to 10 Radiation Therapy Oncology Group sarcoma radiation oncologists with instructions to define GTV and CTV using standardized guidelines. The CT data with contours were then returned for central analysis. Contours representing statistically corrected 95% (V95) and 100% (V100) agreement were computed for each structure. RESULTS: For the GTV, the minimum, maximum, mean (SD) volumes (mL) were 674, 798, 752±35 for the lower extremity case and 383, 543, 447±46 for the upper extremity case. The volume (cc) of the union, V95 and V100 were 882, 761, and 752 for the lower, and 587, 461, and 455 for the upper extremity, respectively. The overall GTV agreement was judged to be almost perfect in both lower and upper extremity cases (kappa=0.9 [p<0.0001] and kappa=0.86 [p<0.0001]). For the CTV, the minimum, maximum, mean (SD) volumes (mL) were 1145, 1911, 1605±211 for the lower extremity case and 637, 1246, 1006±180 for the upper extremity case. The volume (cc) of the union, V95, and V100 were 2094, 1609, and 1593 for the lower, and 1533, 1020, and 965 for the upper extremity cases, respectively. The overall CTV agreement was judged to be almost perfect in the lower extremity case (kappa=0.85 [p<0.0001]) but only substantial in the upper extremity case (kappa=0.77 [p<0.0001]). CONCLUSIONS: Almost perfect agreement existed in the GTV of these two representative cases. There was no significant disagreement in the CTV of the lower extremity, but variation in the CTV of upper extremity was seen, perhaps related to the positional differences between the planning CT and the diagnostic MRI.
PURPOSE: To evaluate variability in the definition of preoperative radiotherapy gross tumor volume (GTV) and clinical target volume (CTV) delineated by sarcoma radiation oncologists. METHODS AND MATERIALS: Extremity sarcoma planning CT images along with the corresponding diagnostic MRI from two patients were distributed to 10 Radiation Therapy Oncology Group sarcoma radiation oncologists with instructions to define GTV and CTV using standardized guidelines. The CT data with contours were then returned for central analysis. Contours representing statistically corrected 95% (V95) and 100% (V100) agreement were computed for each structure. RESULTS: For the GTV, the minimum, maximum, mean (SD) volumes (mL) were 674, 798, 752±35 for the lower extremity case and 383, 543, 447±46 for the upper extremity case. The volume (cc) of the union, V95 and V100 were 882, 761, and 752 for the lower, and 587, 461, and 455 for the upper extremity, respectively. The overall GTV agreement was judged to be almost perfect in both lower and upper extremity cases (kappa=0.9 [p<0.0001] and kappa=0.86 [p<0.0001]). For the CTV, the minimum, maximum, mean (SD) volumes (mL) were 1145, 1911, 1605±211 for the lower extremity case and 637, 1246, 1006±180 for the upper extremity case. The volume (cc) of the union, V95, and V100 were 2094, 1609, and 1593 for the lower, and 1533, 1020, and 965 for the upper extremity cases, respectively. The overall CTV agreement was judged to be almost perfect in the lower extremity case (kappa=0.85 [p<0.0001]) but only substantial in the upper extremity case (kappa=0.77 [p<0.0001]). CONCLUSIONS: Almost perfect agreement existed in the GTV of these two representative cases. There was no significant disagreement in the CTV of the lower extremity, but variation in the CTV of upper extremity was seen, perhaps related to the positional differences between the planning CT and the diagnostic MRI.
Authors: Thomas Rockwell Mackie; Jeff Kapatoes; Ken Ruchala; Weiguo Lu; Chuan Wu; Gustavo Olivera; Lisa Forrest; Wolfgang Tome; Jim Welsh; Robert Jeraj; Paul Harari; Paul Reckwerdt; Bhudatt Paliwal; Mark Ritter; Harry Keller; Jack Fowler; Minesh Mehta Journal: Int J Radiat Oncol Biol Phys Date: 2003-05-01 Impact factor: 7.038
Authors: Di Yan; David Lockman; Alvaro Martinez; John Wong; Donald Brabbins; Frank Vicini; Jian Liang; Larry Kestin Journal: Semin Radiat Oncol Date: 2005-07 Impact factor: 5.934
Authors: A M Davis; B O'Sullivan; R S Bell; R Turcotte; C N Catton; J S Wunder; P Chabot; A Hammond; V Benk; M Isler; C Freeman; K Goddard; A Bezjak; R A Kandel; A Sadura; A Day; K James; D Tu; J Pater; B Zee Journal: J Clin Oncol Date: 2002-11-15 Impact factor: 44.544
Authors: Brian O'Sullivan; Aileen M Davis; Robert Turcotte; Robert Bell; Charles Catton; Pierre Chabot; Jay Wunder; Rita Kandel; Karen Goddard; Anna Sadura; Joseph Pater; Benny Zee Journal: Lancet Date: 2002-06-29 Impact factor: 79.321
Authors: Dian Wang; Walter Bosch; David Roberge; Steven E Finkelstein; Ivy Petersen; Michael Haddock; Yen-Lin E Chen; Naoyuki G Saito; David G Kirsch; Ying J Hitchcock; Aaron H Wolfson; Thomas F DeLaney Journal: Int J Radiat Oncol Biol Phys Date: 2011-06-15 Impact factor: 7.038
Authors: Elizabeth H Baldini; Ross A Abrams; Walter Bosch; David Roberge; Rick L M Haas; Charles N Catton; Daniel J Indelicato; Jeffrey R Olsen; Curtiland Deville; Yen-Lin Chen; Steven E Finkelstein; Thomas F DeLaney; Dian Wang Journal: Int J Radiat Oncol Biol Phys Date: 2015-05-01 Impact factor: 7.038
Authors: Nadya Shusharina; Xiaofeng Liu; Jaume Coll-Font; Anna Foster; Georges El Fakhri; Jonghye Woo; Thomas Bortfeld; Christopher Nguyen Journal: Phys Med Biol Date: 2022-07-22 Impact factor: 4.174
Authors: Daniel Y Joh; Gary D Kao; Surya Murty; Melissa Stangl; Lova Sun; Ajlan Al Zaki; Xiangsheng Xu; Stephen M Hahn; Andrew Tsourkas; Jay F Dorsey Journal: Transl Oncol Date: 2013-12-01 Impact factor: 4.243
Authors: Houda Bahig; David Roberge; Walter Bosch; William Levin; Ivy Petersen; Michael Haddock; Carolyn Freeman; Thomas F Delaney; Ross A Abrams; Danny J Indelicato; Elizabeth H Baldini; Ying Hitchcock; David G Kirsch; Kevin R Kozak; Aaron Wolfson; Dian Wang Journal: Int J Radiat Oncol Biol Phys Date: 2013-03-06 Impact factor: 7.038
Authors: Fien Hoefkens; Charlotte Dehandschutter; Johan Somville; Paul Meijnders; Dirk Van Gestel Journal: Radiat Oncol Date: 2016-10-12 Impact factor: 3.481
Authors: Alexander John Vickers; Niluja Thiruthaneeswaran; Catherine Coyle; Prakash Manoharan; James Wylie; Lucy Kershaw; Ananya Choudhury; Alan Mcwilliam Journal: BJR Open Date: 2019-05-13