Literature DB >> 21275048

Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1.

Jerome Wielens1, Stephen J Headey, John J Deadman, David I Rhodes, Giang T Le, Michael W Parker, David K Chalmers, Martin J Scanlon.   

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Year:  2010        PMID： 21275048     DOI： 10.1002/cmdc.201000483

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  3 in total

1.  Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.

Authors:  Erik Serrao; Bikash Debnath; Hiroyuki Otake; Yuting Kuang; Frauke Christ; Zeger Debyser; Nouri Neamati
Journal:  J Med Chem       Date:  2013-03-18       Impact factor: 7.446

2.  Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challenge.

Authors:  Alexander L Perryman; Daniel N Santiago; Stefano Forli; Diogo Santos Martins; Arthur J Olson
Journal:  J Comput Aided Mol Des       Date:  2014-02-04       Impact factor: 3.686

3.  Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.

Authors:  Roberta Costi; Mathieu Métifiot; Suhman Chung; Giuliana Cuzzucoli Crucitti; Kasthuraiah Maddali; Luca Pescatori; Antonella Messore; Valentina Noemi Madia; Giovanni Pupo; Luigi Scipione; Silvano Tortorella; Francesco Saverio Di Leva; Sandro Cosconati; Luciana Marinelli; Ettore Novellino; Stuart F J Le Grice; Angela Corona; Yves Pommier; Christophe Marchand; Roberto Di Santo
Journal:  J Med Chem       Date:  2014-04-11       Impact factor: 7.446
  3 in total

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