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Literature DB >> 21273816

A database for the analysis of immunity genes in Drosophila: PADMA database.

Mark J Lee¹, Ariful Mondal, Chiyedza Small, Indira Paddibhatla, Akira Kawaguchi, Shubha Govind.

Abstract

While microarray experiments generate voluminous data, discerning trends that support an existing or alternative paradigm is challenging. To synergize hypothesis building and testing, we designed the Pathogen Associated Drosophila MicroArray (PADMA) database for easy retrieval and comparison of microarray results from immunity-related experiments (www.padmadatabase.org). PADMA also allows biologists to upload their microarray-results and compare it with datasets housed within PADMA. We tested PADMA using a preliminary dataset from Ganaspis xanthopoda-infected fly larvae, and uncovered unexpected trends in gene expression, reshaping our hypothesis. Thus, the PADMA database will be a useful resource to fly researchers to evaluate, revise, and refine hypotheses.

Entities: Gene Species

Mesh：

Substances：
Drosophila Proteins

Year: 2011 PMID： 21273816 PMCID： PMC3360108 DOI： 10.4161/fly.5.2.14674

Source DB: PubMed Journal: Fly (Austin) ISSN： 1933-6934 Impact factor: 2.160

20 in total

Review 1. The host defense of Drosophila melanogaster.

Authors: Bruno Lemaitre; Jules Hoffmann
Journal: Annu Rev Immunol Date: 2007 Impact factor: 28.527

2. A supracellular system of actin-lined canals controls biogenesis and release of virulence factors in parasitoid venom glands.

Authors: Roberto Ferrarese; Jorge Morales; Daniel Fimiarz; Bruce A Webb; Shubha Govind
Journal: J Exp Biol Date: 2009-07 Impact factor: 3.312

Review 3. Data pushing: a fly-centric guide to bioinformatics tools.

Authors: James Costello; Amy C Cash; Mehmet M Dalkilic; Justen Andrews
Journal: Fly (Austin) Date: 2008-01-01 Impact factor: 2.160

4. Innate immunity in Drosophila: Pathogens and pathways.

Authors: Shubha Govind
Journal: Insect Sci Date: 2008-02 Impact factor: 3.262

5. Quantitative monitoring of gene expression patterns with a complementary DNA microarray.

Authors: M Schena; D Shalon; R W Davis; P O Brown
Journal: Science Date: 1995-10-20 Impact factor: 47.728

6. Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression.

Authors: Yiorgos Apidianakis; Michael N Mindrinos; Wenzhong Xiao; Gee W Lau; Regina L Baldini; Ronald W Davis; Laurence G Rahme
Journal: Proc Natl Acad Sci U S A Date: 2005-02-04 Impact factor: 11.205

7. BEST: a novel computational approach for comparing gene expression patterns from early stages of Drosophila melanogaster development.

Authors: Sudhir Kumar; Karthik Jayaraman; Sethuraman Panchanathan; Rajalakshmi Gurunathan; Ana Marti-Subirana; Stuart J Newfeld
Journal: Genetics Date: 2002-12 Impact factor: 4.562

A database for the analysis of immunity genes in Drosophila: PADMA database.

Review 1. The host defense of Drosophila melanogaster.

2. A supracellular system of actin-lined canals controls biogenesis and release of virulence factors in parasitoid venom glands.

Review 3. Data pushing: a fly-centric guide to bioinformatics tools.

4. Innate immunity in Drosophila: Pathogens and pathways.

5. Quantitative monitoring of gene expression patterns with a complementary DNA microarray.

6. Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression.

7. BEST: a novel computational approach for comparing gene expression patterns from early stages of Drosophila melanogaster development.

8. Developmental analysis of Ganaspis xanthopoda, a larval parasitoid of Drosophila melanogaster.

9. Contrasting infection strategies in generalist and specialist wasp parasitoids of Drosophila melanogaster.

Review 10. Using FlyAtlas to identify better Drosophila melanogaster models of human disease.

1. Harnessing the natural Drosophila-parasitoid model for integrating insect immunity with functional venomics.

2. Meta-Analysis of Immune Induced Gene Expression Changes in Diverse Drosophila melanogaster Innate Immune Responses.

3. A Drosophila immune response against Ras-induced overgrowth.