| Literature DB >> 21273084 |
Shama Nasim1, ShanShan Pei, Fred K Hagen, Craig T Jordan, Peter A Crooks.
Abstract
Melampomagnolide B has been identified as a new antileukemic sesquiterpene. A biotin-conjugated derivative of melampomagnolide B was designed and synthesized in order to elucidate its mechanism of action. A study of the biochemical interactions of the biotin probe suggests that melampomagnolide B derives its remarkable selectivity for leukemic cells over normal hematopoietic cells from its unique ability to exploit biochemical differences between the two cell types.Entities:
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Year: 2011 PMID： 21273084 DOI： 10.1016/j.bmc.2010.12.045
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641