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Literature DB >> 24656611

Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation.

Venumadhav Janganati¹, Narsimha Reddy Penthala¹, Chad E Cragle², Angus M MacNicol³, Peter A Crooks⁴.

Abstract

Aminoparthenolide derivatives have been prepared by reaction of parthenolide with various heterocyclic amines to afford corresponding Michael addition products. These novel compounds were evaluated for their modulatory effects on Xenopus oocyte maturation. Two compounds, 6e and 6f, were identified that promote G2-M cell cycle progression.

Entities: CellLine Chemical Disease Gene Species

Keywords: Heterocyclic amines; Michael addition; Oocyte maturation; Parthenolide; Progesterone

Mesh：

Substances：

Year: 2014 PMID： 24656611 PMCID： PMC4121966 DOI： 10.1016/j.bmcl.2014.02.067

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

42 in total

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Authors: J E Ferrell
Journal: Bioessays Date: 1999-10 Impact factor: 4.345

2. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.

Authors: Monica L Guzman; Randall M Rossi; Lilliana Karnischky; Xiaojie Li; Derick R Peterson; Dianna S Howard; Craig T Jordan
Journal: Blood Date: 2005-02-01 Impact factor: 22.113

3. Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.

Authors: Michele T Yip-Schneider; Harikrishna Nakshatri; Christopher J Sweeney; Mark S Marshall; Eric A Wiebke; C Max Schmidt
Journal: Mol Cancer Ther Date: 2005-04 Impact factor: 6.261

4. Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.

Authors: S P Hehner; M Heinrich; P M Bork; M Vogt; F Ratter; V Lehmann; K Schulze-Osthoff; W Dröge; M L Schmitz
Journal: J Biol Chem Date: 1998-01-16 Impact factor: 5.157

5. Feverfew: weeding out the root of leukaemia.

Authors: Monica L Guzman; Craig T Jordan
Journal: Expert Opin Biol Ther Date: 2005-09 Impact factor: 4.388

6. The mitogen-activated protein kinase signaling pathway stimulates mos mRNA cytoplasmic polyadenylation during Xenopus oocyte maturation.

Authors: E L Howard; A Charlesworth; J Welk; A M MacNicol
Journal: Mol Cell Biol Date: 1999-03 Impact factor: 4.272

Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation.

Review 1. Xenopus oocyte maturation: new lessons from a good egg.

2. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.

3. Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.

4. Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.

5. Feverfew: weeding out the root of leukaemia.

6. The mitogen-activated protein kinase signaling pathway stimulates mos mRNA cytoplasmic polyadenylation during Xenopus oocyte maturation.

Review 7. Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus.

8. Antileukemic activity of aminoparthenolide analogs.

9. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.

10. MAPK interacts with XGef and is required for CPEB activation during meiosis in Xenopus oocytes.

1. Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression.

2. Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells.