OBJECTIVES: The purpose of this study was to assess the incidence, predictors, and outcome of inappropriate shocks in implantable cardioverter-defibrillator (ICD) patients. BACKGROUND: Despite the benefits of ICD therapy, inappropriate defibrillator shocks continue to be a significant drawback. The prognostic importance of inappropriate shocks outside the setting of a clinical trial remains unclear. METHODS: From 1996 to 2006, all recipients of defibrillator devices equipped with intracardiac electrogram storage were included in the current analysis and clinically assessed at implantation. During follow-up, the occurrence of inappropriate ICD shocks and all-cause mortality was noted. RESULTS: A total of 1,544 ICD patients (79% male, age 61 ± 13 years) were included in the analysis. During the follow-up period of 41 ± 18 months, 13% experienced ≥1 inappropriate shocks. The cumulative incidence steadily increased to 18% at 5-year follow-up. Independent predictors of the occurrence of inappropriate shocks included a history of atrial fibrillation (hazard ratio [HR]: 2.0, p < 0.01) and age younger than 70 years (HR: 1.8, p = 0.01). Experiencing a single inappropriate shock resulted in an increased risk of all-cause mortality (HR: 1.6, p = 0.01). Mortality risk increased with every subsequent shock, up to an HR of 3.7 after 5 inappropriate shocks. CONCLUSIONS: In a large cohort of ICD patients, inappropriate shocks were common. The most important finding is the association between inappropriate shocks and mortality, independent of interim appropriate shocks. Copyright Â
OBJECTIVES: The purpose of this study was to assess the incidence, predictors, and outcome of inappropriate shocks in implantable cardioverter-defibrillator (ICD) patients. BACKGROUND: Despite the benefits of ICD therapy, inappropriate defibrillator shocks continue to be a significant drawback. The prognostic importance of inappropriate shocks outside the setting of a clinical trial remains unclear. METHODS: From 1996 to 2006, all recipients of defibrillator devices equipped with intracardiac electrogram storage were included in the current analysis and clinically assessed at implantation. During follow-up, the occurrence of inappropriate ICD shocks and all-cause mortality was noted. RESULTS: A total of 1,544 ICDpatients (79% male, age 61 ± 13 years) were included in the analysis. During the follow-up period of 41 ± 18 months, 13% experienced ≥1 inappropriate shocks. The cumulative incidence steadily increased to 18% at 5-year follow-up. Independent predictors of the occurrence of inappropriate shocks included a history of atrial fibrillation (hazard ratio [HR]: 2.0, p < 0.01) and age younger than 70 years (HR: 1.8, p = 0.01). Experiencing a single inappropriate shock resulted in an increased risk of all-cause mortality (HR: 1.6, p = 0.01). Mortality risk increased with every subsequent shock, up to an HR of 3.7 after 5 inappropriate shocks. CONCLUSIONS: In a large cohort of ICDpatients, inappropriate shocks were common. The most important finding is the association between inappropriate shocks and mortality, independent of interim appropriate shocks. Copyright Â
Authors: Jörg Otto Schwab; Hendrik Bonnemeier; Thomas Kleemann; Johannes Brachmann; Sven Fischer; Frank Birkenhauer; Frank Eberhardt Journal: Clin Res Cardiol Date: 2015-05-23 Impact factor: 5.460
Authors: Jonathan S Gordon; Elizabeth J Maynes; Thomas J O'Malley; Behzad B Pavri; Vakhtang Tchantchaleishvili Journal: J Interv Card Electrophysiol Date: 2021-01-12 Impact factor: 1.900
Authors: Erdal Safak; Lars Eckardt; Werner Jung; Hüseyin Ince; Jochen Senges; Matthias Hochadel; Christian Perings; Stefan Spitzer; Johannes Brachmann; Karlheinz Seidl; Hans Ulrich Hink; Giuseppe D'Ancona Journal: J Interv Card Electrophysiol Date: 2019-08-02 Impact factor: 1.900