BACKGROUND: The aim of this study was to determine the minimum effective volume of lidocaine 1.5% with epinephrine 5 μg/mL in 90% of patients (MEV(90)) for single-injection ultrasound-guided infraclavicular block (ICB). METHODS: Using an in-plane technique, a single-injection ultrasound-guided ICB was performed: a 17-gauge, 8-cm Tuohy needle was advanced until the tip was located dorsal to the axillary artery. Volume assignment was carried out using a biased coin design up-and-down sequential method, where the volume of local anesthetic administered to each patient depended on the response of the previous one. In case of failure, the next subject received a higher volume (defined as the previous volume with an increment of 2.5 mL). If the previous patient had a successful block, the next subject was randomized to a lower volume (defined as the previous volume with a decrement of 2.5 mL), with a probability of b=0.11, or the same volume, with a probability of 1-b=0.89. Lidocaine 1.5% with epinephrine 5 μg/mL was used in all subjects. Success was defined, at 30 mins, as a minimal score of 14 of 16 points using a composite scale encompassing sensory and motor block. Patients undergoing surgery of the elbow, forearm, wrist, or hand were prospectively enrolled until 45 successful blocks were obtained. RESULTS: Fifty-five patients were included in the study. Using isotonic regression and bootstrap confidence interval (CI), the MEV(90) for single-injection ultrasound-guided ICB was estimated to be 35 mL (95% CI, 30-37.5 mL). The probability of a successful response at 35 mL was estimated to be 0.91 (95% CI, 0.8-1.0). All patients with a minimal composite score of 14 points at 30 mins achieved surgical anesthesia intraoperatively. CONCLUSIONS: For single-injection ultrasound-guided ICB, the MEV(90) of lidocaine 1.5% with epinephrine 5 μg/mL is 35 mL. Further dose-finding studies are required for other concentrations of lidocaine, other local anesthetic agents as well as techniques involving multiple injections, a more medial approach to ICB, or precise location of all 3 cords of the brachial plexus.
BACKGROUND: The aim of this study was to determine the minimum effective volume of lidocaine 1.5% with epinephrine 5 μg/mL in 90% of patients (MEV(90)) for single-injection ultrasound-guided infraclavicular block (ICB). METHODS: Using an in-plane technique, a single-injection ultrasound-guided ICB was performed: a 17-gauge, 8-cm Tuohy needle was advanced until the tip was located dorsal to the axillary artery. Volume assignment was carried out using a biased coin design up-and-down sequential method, where the volume of local anesthetic administered to each patient depended on the response of the previous one. In case of failure, the next subject received a higher volume (defined as the previous volume with an increment of 2.5 mL). If the previous patient had a successful block, the next subject was randomized to a lower volume (defined as the previous volume with a decrement of 2.5 mL), with a probability of b=0.11, or the same volume, with a probability of 1-b=0.89. Lidocaine 1.5% with epinephrine 5 μg/mL was used in all subjects. Success was defined, at 30 mins, as a minimal score of 14 of 16 points using a composite scale encompassing sensory and motor block. Patients undergoing surgery of the elbow, forearm, wrist, or hand were prospectively enrolled until 45 successful blocks were obtained. RESULTS: Fifty-five patients were included in the study. Using isotonic regression and bootstrap confidence interval (CI), the MEV(90) for single-injection ultrasound-guided ICB was estimated to be 35 mL (95% CI, 30-37.5 mL). The probability of a successful response at 35 mL was estimated to be 0.91 (95% CI, 0.8-1.0). All patients with a minimal composite score of 14 points at 30 mins achieved surgical anesthesia intraoperatively. CONCLUSIONS: For single-injection ultrasound-guided ICB, the MEV(90) of lidocaine 1.5% with epinephrine 5 μg/mL is 35 mL. Further dose-finding studies are required for other concentrations of lidocaine, other local anesthetic agents as well as techniques involving multiple injections, a more medial approach to ICB, or precise location of all 3 cords of the brachial plexus.
Authors: G Eren; E Altun; Y Pektas; Y Polat; H Cetingok; G Demir; D Bilgi; Y Tekdos; M Dogan Journal: Anaesthesist Date: 2014-08-08 Impact factor: 1.041
Authors: Chun Woo Yang; Po Soon Kang; Hee Uk Kwon; Kyu Chang Lee; Myeong Jong Lee; Hye Young Kim; Eun Kyung Choi; Hyun Kyoung Lim; Chul Woung Kim Journal: Korean J Anesthesiol Date: 2012-07-24
Authors: Trine Kåsine; Luis Romundstad; L A Rosseland; Morten Wang Fagerland; Paul Kessler; Ivar Nagelgaard Omenås; Anne Holmberg; Axel R Sauter Journal: Reg Anesth Pain Med Date: 2020-06-14 Impact factor: 6.288