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Literature DB >> 21266574

A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.

Alessia P M Barbagallo¹, Zilai Wang, Hui Zheng, Luciano D'Adamio.

Abstract

The Aβ-precursor protein (APP) intracellular domain is highly conserved and contains many potentially important residues, in particular the (682)YENPTY(687) motif. To dissect the functions of this sequence in vivo, we created an APP knock-in allele mutating Tyr(682) to Gly (Y682G). Crossing this allele to APP-like protein 2 (APLP2) knock-out background showed that mutation of Tyr(682) results in postnatal lethality and neuromuscular synapse defects similar to doubly deficient APP/APLP2 mice. Our results demonstrate that a single residue in the APP intracellular region, Tyr(682), is indispensable for the essential function of APP in developmental regulation.

Entities: Chemical Disease Gene Species

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Year: 2011 PMID： 21266574 PMCID： PMC3059018 DOI： 10.1074/jbc.C111.219873

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

38 in total

1. Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein.

Authors: G R Dawson; G R Seabrook; H Zheng; D W Smith; S Graham; G O'Dowd; B J Bowery; S Boyce; M E Trumbauer; H Y Chen; L H Van der Ploeg; D J Sirinathsinghji
Journal: Neuroscience Date: 1999-04 Impact factor: 3.590

2. Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.

Authors: Z Zhang; C H Lee; V Mandiyan; J P Borg; B Margolis; J Schlessinger; J Kuriyan
Journal: EMBO J Date: 1997-10-15 Impact factor: 11.598

Review 3. Signal-dependent membrane protein trafficking in the endocytic pathway.

Authors: I S Trowbridge; J F Collawn; C R Hopkins
Journal: Annu Rev Cell Biol Date: 1993

4. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.

Authors: Hongmei Li; Baiping Wang; Zilai Wang; Qinxi Guo; Katsuhiko Tabuchi; Robert E Hammer; Thomas C Südhof; Hui Zheng
Journal: Proc Natl Acad Sci U S A Date: 2010-09-20 Impact factor: 11.205

5. APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability.

Authors: Angela Hornsten; Jason Lieberthal; Shruti Fadia; Richard Malins; Lawrence Ha; Xiaomeng Xu; Isabelle Daigle; Mindy Markowitz; Gregory O'Connor; Ronald Plasterk; Chris Li
Journal: Proc Natl Acad Sci U S A Date: 2007-01-31 Impact factor: 11.205

6. Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.

Authors: Philip E Tarr; Roberta Roncarati; Giuliana Pelicci; Pier Giuseppe Pelicci; Luciano D'Adamio
Journal: J Biol Chem Date: 2002-03-04 Impact factor: 5.157

7. JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65.

Authors: Meir H Scheinfeld; Shuji Matsuda; Luciano D'Adamio
Journal: Proc Natl Acad Sci U S A Date: 2003-01-31 Impact factor: 11.205

8. Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene.

Authors: P Tremml; H P Lipp; U Müller; L Ricceri; D P Wolfer
Journal: Behav Brain Res Date: 1998-09 Impact factor: 3.332

9. Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

Authors: B Passer; L Pellegrini; C Russo; R M Siegel; M J Lenardo; G Schettini; M Bachmann; M Tabaton; L D'Adamio
Journal: J Alzheimers Dis Date: 2000-11 Impact factor: 4.472

10. Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role.

Authors: Luca Giliberto; Dawang Zhou; Richard Weldon; Elena Tamagno; Pasquale De Luca; Massimo Tabaton; Luciano D'Adamio
Journal: Mol Neurodegener Date: 2008-09-02 Impact factor: 14.195

31 in total

Review 1. Functions of the APP gene family in the nervous system: insights from mouse models.

Authors: Dorothee Aydin; Sascha W Weyer; Ulrike C Müller
Journal: Exp Brain Res Date: 2011-09-20 Impact factor: 1.972

2. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.

Authors: Dolores Del Prete; Richard C Rice; Anjali M Rajadhyaksha; Luciano D'Adamio
Journal: J Biol Chem Date: 2016-06-20 Impact factor: 5.157

3. Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.

Authors: Carmela Matrone; Siro Luvisetto; Luca R La Rosa; Robert Tamayev; Annabella Pignataro; Nadia Canu; Li Yang; Alessia P M Barbagallo; Fabrizio Biundo; Franco Lombino; Hui Zheng; Martine Ammassari-Teule; Luciano D'Adamio
Journal: Aging Cell Date: 2012-10-12 Impact factor: 9.304

A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.

1. Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein.

2. Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.

Review 3. Signal-dependent membrane protein trafficking in the endocytic pathway.

4. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.

5. APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability.

6. Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.

7. JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65.

8. Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene.

9. Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

10. Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role.

Review 1. Functions of the APP gene family in the nervous system: insights from mouse models.

2. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.

3. Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.

Review 4. APP physiological and pathophysiological functions: insights from animal models.

Review 5. Not just amyloid: physiological functions of the amyloid precursor protein family.

6. APP is phosphorylated by TrkA and regulates NGF/TrkA signaling.

Review 7. Physiological functions of APP family proteins.

8. Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function.

9. Amyloid precursor protein (APP) regulates synaptic structure and function.

Review 10. The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes.