Literature DB >> 28360418

Not just amyloid: physiological functions of the amyloid precursor protein family.

Ulrike C Müller1, Thomas Deller2, Martin Korte3,4.   

Abstract

Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP and the closely related APP-like proteins (APLPs) remain less well understood. Studying these physiological functions has been challenging and has required a careful long-term strategy, including the analysis of different App-knockout and Aplp-knockout mice. In this Review, we summarize these findings, focusing on the in vivo roles of APP family members and their processing products for CNS development, synapse formation and function, brain injury and neuroprotection, as well as ageing. In addition, we discuss the implications of APP physiology for therapeutic approaches.

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Year:  2017        PMID： 28360418     DOI： 10.1038/nrn.2017.29

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN： 1471-003X            Impact factor:   34.870


  210 in total

1.  Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits.

Authors:  J J Anderson; G Holtz; P P Baskin; R Wang; L Mazzarelli; S L Wagner; F Menzaghi
Journal:  Neuroscience       Date:  1999       Impact factor: 3.590

2.  Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo.

Authors:  Peter Jedlicka; Mirka Owen; Matej Vnencak; Jakob-A Tschäpe; Meike Hick; Ulrike C Müller; Thomas Deller
Journal:  Exp Brain Res       Date:  2011-11-11       Impact factor: 1.972

3.  Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.

Authors:  R D Terry; E Masliah; D P Salmon; N Butters; R DeTeresa; R Hill; L A Hansen; R Katzman
Journal:  Ann Neurol       Date:  1991-10       Impact factor: 10.422

4.  Behavioral and neuropathologic changes induced by central injection of carboxyl-terminal fragment of beta-amyloid precursor protein in mice.

Authors:  D K Song; M H Won; J S Jung; J C Lee; T C Kang; H W Suh; S O Huh; S H Paek; Y H Kim; S H Kim; Y H Suh
Journal:  J Neurochem       Date:  1998-08       Impact factor: 5.372

5.  Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth.

Authors:  Nicolas Rama; David Goldschneider; Véronique Corset; Jérémy Lambert; Laurent Pays; Patrick Mehlen
Journal:  J Biol Chem       Date:  2012-07-10       Impact factor: 5.157

Review 6.  The role of protein clearance mechanisms in organismal ageing and age-related diseases.

Authors:  David Vilchez; Isabel Saez; Andrew Dillin
Journal:  Nat Commun       Date:  2014-12-08       Impact factor: 14.919

7.  Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.

Authors:  Sarah E Hoey; Robert J Williams; Michael S Perkinton
Journal:  J Neurosci       Date:  2009-04-08       Impact factor: 6.167

Review 8.  The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes.

Authors:  Hoang S Nhan; Karen Chiang; Edward H Koo
Journal:  Acta Neuropathol       Date:  2014-10-07       Impact factor: 17.088

9.  In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice.

Authors:  Jose Morales-Corraliza; Matthew J Mazzella; Jason D Berger; Nicole S Diaz; Jennifer H K Choi; Efrat Levy; Yasuji Matsuoka; Emmanuel Planel; Paul M Mathews
Journal:  PLoS One       Date:  2009-09-22       Impact factor: 3.240

10.  Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance.

Authors:  Lucas J Sosa; Jared Bergman; Adriana Estrada-Bernal; Thomas J Glorioso; John M Kittelson; Karl H Pfenninger
Journal:  PLoS One       Date:  2013-05-14       Impact factor: 3.240
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  152 in total

1.  Determining the Protein Stability of Alzheimer's Disease Protein, Amyloid Precursor Protein.

Authors:  Alexandré Delport; Raymond Hewer
Journal:  Protein J       Date:  2019-08       Impact factor: 2.371

Review 2.  The physiological role of α-synuclein and its relationship to Parkinson's Disease.

Authors:  David Sulzer; Robert H Edwards
Journal:  J Neurochem       Date:  2019-07-28       Impact factor: 5.372

Review 3.  The role of UNC5C in Alzheimer's disease.

Authors:  Quan Li; Bai-Ling Wang; Fu-Rong Sun; Jie-Qiong Li; Xi-Peng Cao; Lan Tan
Journal:  Ann Transl Med       Date:  2018-05

4.  Abnormal clotting of the intrinsic/contact pathway in Alzheimer disease patients is related to cognitive ability.

Authors:  Georgette L Suidan; Pradeep K Singh; Sunita Patel-Hett; Zu-Lin Chen; Dmitri Volfson; Hitomi Yamamoto-Imoto; Erin H Norris; Robert D Bell; Sidney Strickland
Journal:  Blood Adv       Date:  2018-05-08

5.  Inner Workings: Family of protein fragments promises fresh view of Alzheimer's disease.

Authors:  Charlotte Schubert
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-04       Impact factor: 11.205

6.  APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.

Authors:  Carole Deyts; Mary Clutter; Nicholas Pierce; Paramita Chakrabarty; Thomas B Ladd; Anna Goddi; Awilda M Rosario; Pedro Cruz; Kulandaivelu Vetrivel; Steven L Wagner; Gopal Thinakaran; Todd E Golde; Angèle T Parent
Journal:  Cell Rep       Date:  2019-04-30       Impact factor: 9.423

7.  Amyloidosis by Bacterial Infection in Critically Ill Patients?

Authors:  Yvonne S Eisele
Journal:  Am J Respir Crit Care Med       Date:  2018-12-15       Impact factor: 21.405

8.  Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin.

Authors:  Vivek Venkataramani; Thorsten R Doeppner; Desiree Willkommen; Catherine M Cahill; Yongjuan Xin; Guilin Ye; Yanyan Liu; Adam Southon; Allegra Aron; Ho Yu Au-Yeung; Xudong Huang; Debomoy K Lahiri; Fudi Wang; Ashley I Bush; Gerald G Wulf; Philipp Ströbel; Bernhard Michalke; Jack T Rogers
Journal:  J Neurochem       Date:  2018-11-19       Impact factor: 5.372

9.  Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer's disease.

Authors:  Teneka Jean-Louis; Patricia Rockwell; Maria E Figueiredo-Pereira
Journal:  Neurobiol Aging       Date:  2017-11-14       Impact factor: 4.673

10.  Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux.

Authors:  Adrienne C Dlouhy; Danielle K Bailey; Brittany L Steimle; Haley V Parker; Daniel J Kosman
Journal:  J Biol Chem       Date:  2019-01-15       Impact factor: 5.157
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