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Literature DB >> 2126321

Inhibition of the activity of human leukocyte elastase by lipids particularly oleic acid and retinoic acid.

Abstract

The effect of various natural hydrophobic lipids on the in vitro and in vivo activity of human leukocyte elastase has been examined. In vitro studies using 2 different substrates indicated that fatty acids inhibit human leukocyte elastase activity, with maximum inhibition observed with oleic acid. Triolein, cholesterol, and beta-carotene caused little inhibition. The presence of a carboxyl group appears important since retinoic acid but not retinol also inhibited activity. In vivo studies of an emphysema model in mice indicated that intrapulmonary instillation of oleic or retinoic acid reduced lung injury caused by human leukocyte elastase. The possibility of using these compounds to diminish elastolytic damage in emphysema is raised.

Entities: Chemical Disease Gene Species

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Year: 1990 PMID： 2126321 DOI： 10.1007/bf02719709

Source DB: PubMed Journal: Lung ISSN： 0341-2040 Impact factor: 2.584

19 in total

1. The action of elastase on p-nitroanilide substrates.

Authors: J Bieth; C G Wermuth
Journal: Biochem Biophys Res Commun Date: 1973-07-17 Impact factor: 3.575

2. Proteolysis of elastin-ligand complexes. Stimulation of elastase digestion of insoluble elastin by sodium dodecyl sulfate.

Authors: H M Kagan; G D Crombie; R E Jordan; W Lewis; C Franzblau
Journal: Biochemistry Date: 1972-08-29 Impact factor: 3.162

3. Specific inhibition of human granulocyte elastase by cis-unsaturated fatty acids and activation by the corresponding alcohols.

Authors: B M Ashe; M Zimmerman
Journal: Biochem Biophys Res Commun Date: 1977-03-07 Impact factor: 3.575

Review 4. Elastase in tissue injury.

Authors: A Janoff
Journal: Annu Rev Med Date: 1985 Impact factor: 13.739

5. A rapid method of purification of human granulocyte cationic neutral proteases: purification and further characterization of human granulocyte elastase.

Authors: G Feinstein; A Janoff
Journal: Biochim Biophys Acta Date: 1975-10-22

6. Reaction of azapeptides with human leukocyte elastase and porcine pancreatic elastase. New inhibitors and active site titrants.

Authors: J C Powers; R Boone; D L Carroll; B F Gupton; C M Kam; N Nishino; M Sakamoto; P M Tuhy
Journal: J Biol Chem Date: 1984-04-10 Impact factor: 5.157

Inhibition of the activity of human leukocyte elastase by lipids particularly oleic acid and retinoic acid.

1. The action of elastase on p-nitroanilide substrates.

2. Proteolysis of elastin-ligand complexes. Stimulation of elastase digestion of insoluble elastin by sodium dodecyl sulfate.

3. Specific inhibition of human granulocyte elastase by cis-unsaturated fatty acids and activation by the corresponding alcohols.

Review 4. Elastase in tissue injury.

5. A rapid method of purification of human granulocyte cationic neutral proteases: purification and further characterization of human granulocyte elastase.

6. Reaction of azapeptides with human leukocyte elastase and porcine pancreatic elastase. New inhibitors and active site titrants.

7. Fatty acid peptide derivatives as model compounds to protect elastin against degradation by elastases.

8. Catalysis by human leukocyte elastase: III. Steady-state kinetics for the hydrolysis of p-nitrophenyl esters.

9. Similar binding sites for unsaturated fatty acids and alkyl 2-pyrone inhibitors of human sputum elastase.

10. Inhibition of human sputum elastase by substituted 2-pyrones.

1. 5,9,23-Triacontatrienoic methyl ester, an elastase inhibitor from the marine sponge Chondrilla nucula.