| Literature DB >> 21259426 |
Steno L de Oliveira1, Josean F Tavares, Marianna V S Castello Branco, Hellane F S Lucena, José M Barbosa-Filho, Maria de F Agra, Silene C do Nascimento, Jaciana dos S Aguiar, Teresinha G da Silva, Carlos A de Simone, João X de Araújo-Júnior, Marcelo S da Silva.
Abstract
Three tropane alkaloids, 1-3, were isolated from Erythroxylum caatingae, i.e., 6β-benzoyloxy-3α-[(4-hydroxy-3,5-dimethoxybenzoyl)oxy]tropane (1), a new tropane alkaloid, along with the known alkaloids 3α,6β-dibenzoyloxytropane (2) and 6β-benzoyloxy-3α-[(3,4,5-trimethoxybenzoyl)oxy]tropane (catuabine B; 3). Their structures were determined by 2D- ((1) H and (13) C) NMR. By LC/ESI-MS/MS analysis of the fractions of alkaloids 1-3, it was possible to detect five more alkaloids, 4-8, two of these, 4 and 8, possibly being new natural products. X-Ray crystallography of the chloride derivate of 1, i.e., 6β-benzoyloxy-3α-(4-hydroxy-3,5-dimethoxybenzoyloxy)tropane hydrochloride (1a) confirmed the structure of 1. Cytotoxicity was tested against the cell lines HEp-2, NCI-H292, and KB for the MeOH extract and alkaloid 3, and antitumor activity was tested against Sarcoma 180 only for the MeOH extract.Entities:
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Year: 2011 PMID： 21259426 DOI： 10.1002/cbdv.200900400
Source DB: PubMed Journal: Chem Biodivers ISSN： 1612-1872 Impact factor: 2.408