BACKGROUND: Oral hygiene is attracting increasing attention as a potential risk factor for cancers. To investigate the association between toothbrushing frequency and upper aerodigestive tract (UADT) cancer, the authors conducted a large-scale case-control study. METHODS: A total of 856 UADT cancer case participants and 2696 age- and sex-matched control subjects without cancer were included. Edentulous or participants with unknown frequency of toothbrushing or number of remaining teeth were excluded. Associations were assessed by odds ratios and 95% confidence intervals in logistic regression models with adjustment for potential confounders. RESULTS: Compared with toothbrushing once per day, the adjusted odds ratio for brushing twice or more was 0.82 (95% confidence interval: 0.68, 0.99) whereas that for not brushing was 1.79 (0.79, 4.05). This association was observed especially in subjects who had a history of heavy smoking or drinking. CONCLUSIONS: The authors suggest that toothbrushing could have a protective effect for UADT cancer.
BACKGROUND: Oral hygiene is attracting increasing attention as a potential risk factor for cancers. To investigate the association between toothbrushing frequency and upper aerodigestive tract (UADT) cancer, the authors conducted a large-scale case-control study. METHODS: A total of 856 UADT cancer case participants and 2696 age- and sex-matched control subjects without cancer were included. Edentulous or participants with unknown frequency of toothbrushing or number of remaining teeth were excluded. Associations were assessed by odds ratios and 95% confidence intervals in logistic regression models with adjustment for potential confounders. RESULTS: Compared with toothbrushing once per day, the adjusted odds ratio for brushing twice or more was 0.82 (95% confidence interval: 0.68, 0.99) whereas that for not brushing was 1.79 (0.79, 4.05). This association was observed especially in subjects who had a history of heavy smoking or drinking. CONCLUSIONS: The authors suggest that toothbrushing could have a protective effect for UADT cancer.
Authors: Xingdong Chen; Björn Winckler; Ming Lu; Hongwei Cheng; Ziyu Yuan; Yajun Yang; Li Jin; Weimin Ye Journal: PLoS One Date: 2015-12-07 Impact factor: 3.240
Authors: Daniela Börnigen; Boyu Ren; Robert Pickard; Jingfeng Li; Enver Ozer; Erica M Hartmann; Weihong Xiao; Timothy Tickle; Jennifer Rider; Dirk Gevers; Eric A Franzosa; Mary Ellen Davey; Maura L Gillison; Curtis Huttenhower Journal: Sci Rep Date: 2017-12-15 Impact factor: 4.379