Daisuke Kawakita1,2,3, Yuan-Chin Amy Lee1, Qian Li4, Yuji Chen1, Chien-Jen Chen5,6, Wan-Lun Hsu5, Pei-Jen Lou7, Cairong Zhu8, Jian Pan9, Hongbing Shen10, Hongxia Ma10, Lin Cai11, Baochang He11, Yu Wang12, Xiaoyan Zhou13, Qinghai Ji12, Baosen Zhou14, Wei Wu14, Jie Ma15, Paolo Boffetta16, Zuo-Feng Zhang17, Min Dai18, Mia Hashibe1. 1. Division of Public Health, Department of Family and Preventive Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah. 2. Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. 3. Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan. 4. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. 5. Genomics Research Center, Academia Sinica, Taipei, Taiwan. 6. Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan. 7. Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan. 8. Department of Epidemiology and Biostatistics, West China Center of Medical Sciences, Sichuan University, Sichuan, China. 9. Department of Oral Surgery, West China Hospital of Stomatology, Sichuan University, Sichuan, China. 10. Department of Epidemiology and Biostatistics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China. 11. Department of Epidemiology and Biostatistics, School of Public Health, Fujian Medical University, Fuzhou, China. 12. Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 13. Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Shanghai, China. 14. Department of Epidemiology, School of Public Health, China Medical University, Liaoning, China. 15. Department of Head and Neck Oncology, Henan Cancer Hospital, Zhengzhou, China. 16. Institute for Translational Epidemiology and Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York. 17. Department of Epidemiology, and Center for Environmental Genomics, University of California - Los Angeles, Fielding School of Public Health, Los Angeles, California. 18. National Office of Cancer Prevention and Control Cancer Institute and Hospital, and Chinese Academy of Medical Sciences, Beijing, China.
Abstract
BACKGROUND: Although the impact of oral hygiene on head and neck cancer risk has been investigated, few studies have been conducted among the Asian population. METHODS: We conducted a multicenter case-control study to investigate this potential association. We performed unconditional multiple logistic regression models adjusted by potential confounders. RESULTS: We observed an inverse association of frequency of dental visits with head and neck cancer risk, with an adjusted odds ratio (OR) of 3.70 (95% CI 2.51-5.45) for never dental visits compared with ≥1 time/year (Ptrend < .001). We also observed a positive association between the number of missing teeth and head and neck cancer risk, with an adjusted OR for ≥5 missing teeth compared with <5 missing teeth of 1.49 (95% CI 1.08-2.04). Combining multiple oral hygiene indicators, poor oral hygiene scores increased head and neck cancer risk. CONCLUSION: Poor oral hygiene may increase head and neck cancer risk in the Chinese population. Therefore, improving oral hygiene may contribute to reducing the head and neck cancer risk in the Chinese population.
BACKGROUND: Although the impact of oral hygiene on head and neck cancer risk has been investigated, few studies have been conducted among the Asian population. METHODS: We conducted a multicenter case-control study to investigate this potential association. We performed unconditional multiple logistic regression models adjusted by potential confounders. RESULTS: We observed an inverse association of frequency of dental visits with head and neck cancer risk, with an adjusted odds ratio (OR) of 3.70 (95% CI 2.51-5.45) for never dental visits compared with ≥1 time/year (Ptrend < .001). We also observed a positive association between the number of missing teeth and head and neck cancer risk, with an adjusted OR for ≥5 missing teeth compared with <5 missing teeth of 1.49 (95% CI 1.08-2.04). Combining multiple oral hygiene indicators, poor oral hygiene scores increased head and neck cancer risk. CONCLUSION: Poor oral hygiene may increase head and neck cancer risk in the Chinese population. Therefore, improving oral hygiene may contribute to reducing the head and neck cancer risk in the Chinese population.
Authors: Neela Guha; Paolo Boffetta; Victor Wünsch Filho; Jose Eluf Neto; Oxana Shangina; David Zaridze; Maria Paula Curado; Sergio Koifman; Elena Matos; Ana Menezes; Neonila Szeszenia-Dabrowska; Leticia Fernandez; Dana Mates; Alexander W Daudt; Jolanta Lissowska; Rajesh Dikshit; Paul Brennan Journal: Am J Epidemiol Date: 2007-08-30 Impact factor: 4.897
Authors: T Z Zheng; P Boyle; H F Hu; J Duan; P J Jian; D Q Ma; L P Shui; S R Niu; C Scully; B MacMahon Journal: Cancer Causes Control Date: 1990-11 Impact factor: 2.506
Authors: D Hashim; S Sartori; P Brennan; M P Curado; V Wünsch-Filho; K Divaris; A F Olshan; J P Zevallos; D M Winn; S Franceschi; X Castellsagué; J Lissowska; P Rudnai; K Matsuo; H Morgenstern; C Chen; T L Vaughan; J N Hofmann; G D'Souza; R I Haddad; H Wu; Y-C Lee; M Hashibe; C La Vecchia; P Boffetta Journal: Ann Oncol Date: 2016-05-27 Impact factor: 32.976
Authors: Melissa N Eliot; Dominique S Michaud; Scott M Langevin; Michael D McClean; Karl T Kelsey Journal: Cancer Causes Control Date: 2013-04-09 Impact factor: 2.506
Authors: L F Garrote; R Herrero; R M Reyes; S Vaccarella; J L Anta; L Ferbeye; N Muñoz; S Franceschi Journal: Br J Cancer Date: 2001-07-06 Impact factor: 7.640
Authors: Llara Prieto-Fernández; Sofía T Menéndez; María Otero-Rosales; Irene Montoro-Jiménez; Francisco Hermida-Prado; Juana M García-Pedrero; Saúl Álvarez-Teijeiro Journal: Front Cell Dev Biol Date: 2022-09-28