Literature DB >> 21832279

Blood platelets contain tumor-derived RNA biomarkers.

R Jonas A Nilsson1, Leonora Balaj, Esther Hulleman, Sjoerd van Rijn, D Michiel Pegtel, Maudy Walraven, Anders Widmark, Winald R Gerritsen, Henk M Verheul, W Peter Vandertop, David P Noske, Johan Skog, Thomas Würdinger.   

Abstract

Diagnostic platforms providing biomarkers that are highly predictive for diagnosing, monitoring, and stratifying cancer patients are key instruments in the development of personalized medicine. We demonstrate that tumor cells transfer (mutant) RNA into blood platelets in vitro and in vivo, and show that blood platelets isolated from glioma and prostate cancer patients contain the cancer-associated RNA biomarkers EGFRvIII and PCA3, respectively. In addition, gene-expression profiling revealed a distinct RNA signature in platelets from glioma patients compared with normal control subjects. Because platelets are easily accessible and isolated, they may form an attractive platform for the companion diagnostics of cancer.

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Year:  2011        PMID： 21832279      PMCID： PMC7224637          DOI： 10.1182/blood-2011-03-344408

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  33 in total

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Journal:  Semin Thromb Hemost       Date:  2010-11-03       Impact factor: 4.180

3.  miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets.

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Journal:  Blood       Date:  2010-05-05       Impact factor: 22.113

4.  Exosomes: Fit to deliver small RNA.

Authors:  Anoek Zomer; Tineke Vendrig; Erik S Hopmans; Monique van Eijndhoven; Jaap M Middeldorp; D Michiel Pegtel
Journal:  Commun Integr Biol       Date:  2010-09

5.  Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events.

Authors:  Luca Cecchetti; Neal D Tolley; Noemi Michetti; Loredana Bury; Andrew S Weyrich; Paolo Gresele
Journal:  Blood       Date:  2011-05-31       Impact factor: 22.113

6.  Functional delivery of viral miRNAs via exosomes.

Authors:  D Michiel Pegtel; Katherine Cosmopoulos; David A Thorley-Lawson; Monique A J van Eijndhoven; Erik S Hopmans; Jelle L Lindenberg; Tanja D de Gruijl; Thomas Würdinger; Jaap M Middeldorp
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-18       Impact factor: 11.205

7.  Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer.

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8.  Platelet-associated PF-4 as a biomarker of early tumor growth.

Authors:  David Cervi; Tai-Tung Yip; Nandita Bhattacharya; Vladimir N Podust; Jon Peterson; Abdo Abou-Slaybi; George N Naumov; Elise Bender; Nava Almog; Joseph E Italiano; Judah Folkman; Giannoula L Klement
Journal:  Blood       Date:  2007-10-03       Impact factor: 22.113

9.  MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins.

Authors:  Kasey C Vickers; Brian T Palmisano; Bassem M Shoucri; Robert D Shamburek; Alan T Remaley
Journal:  Nat Cell Biol       Date:  2011-03-20       Impact factor: 28.824

10.  Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.

Authors:  Johan Skog; Tom Würdinger; Sjoerd van Rijn; Dimphna H Meijer; Laura Gainche; Miguel Sena-Esteves; William T Curry; Bob S Carter; Anna M Krichevsky; Xandra O Breakefield
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  114 in total

1.  Platelets and platelet-like particles mediate intercellular RNA transfer.

Authors:  Antonina Risitano; Lea M Beaulieu; Olga Vitseva; Jane E Freedman
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2.  An Automated Microfluidic Assay for Photonic Crystal Enhanced Detection and Analysis of an Antiviral Antibody Cancer Biomarker in Serum.

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Journal:  IEEE Sens J       Date:  2017-11-24       Impact factor: 3.301

Review 3.  The Platelet Lifeline to Cancer: Challenges and Opportunities.

Authors:  Monika Haemmerle; Rebecca L Stone; David G Menter; Vahid Afshar-Kharghan; Anil K Sood
Journal:  Cancer Cell       Date:  2018-04-12       Impact factor: 31.743

4.  Exploration of genome-wide circulating microRNA in hepatocellular carcinoma: MiR-483-5p as a potential biomarker.

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5.  Real-time liquid biopsies become a reality in cancer treatment.

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6.  RNA sequencing and swarm intelligence-enhanced classification algorithm development for blood-based disease diagnostics using spliced blood platelet RNA.

Authors:  Myron G Best; Sjors G J G In 't Veld; Nik Sol; Thomas Wurdinger
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Review 7.  Platelets as crucial partners for tumor metastasis: from mechanistic aspects to pharmacological targeting.

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Review 8.  Circulating glioma biomarkers.

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Review 9.  Blood-based tumor biomarkers in lung cancer for detection and treatment.

Authors:  Hirva Mamdani; Shahid Ahmed; Samantha Armstrong; Tony Mok; Shadia I Jalal
Journal:  Transl Lung Cancer Res       Date:  2017-12

Review 10.  Extracellular vesicles shed by glioma cells: pathogenic role and clinical value.

Authors:  Dimitry A Chistiakov; Vladimir P Chekhonin
Journal:  Tumour Biol       Date:  2014-06-27
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