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Literature DB >> 21252997

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.

Chris Jopling¹, Stephanie Boue, Juan Carlos Izpisua Belmonte.

Abstract

The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming. Recent advances have shown that the addition of a group of genes can not only restore pluripotency in a fully differentiated cell state (reprogramming) but can also induce the cell to proliferate (dedifferentiation) or even switch to another cell type (transdifferentiation). Current research aims to understand how these processes work and to eventually harness them for use in regenerative medicine.

Mesh：

Year: 2011 PMID： 21252997 DOI： 10.1038/nrm3043

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

108 in total

1. Transcriptomics approach to investigate zebrafish heart regeneration.

Authors: Eduard Sleep; Stéphanie Boué; Chris Jopling; Marina Raya; Angel Raya; Juan Carlos Izpisua Belmonte
Journal: J Cardiovasc Med (Hagerstown) Date: 2010-05 Impact factor: 2.160

2. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.

Authors: J G Flanagan; D C Chan; P Leder
Journal: Cell Date: 1991-03-08 Impact factor: 41.582

3. Physical interaction between TBX5 and MEF2C is required for early heart development.

Authors: Tushar K Ghosh; Fei Fei Song; Elizabeth A Packham; Sarah Buxton; Thelma E Robinson; Jonathan Ronksley; Tim Self; Andrew J Bonser; J David Brook
Journal: Mol Cell Biol Date: 2009-02-09 Impact factor: 4.272

4. Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression.

Authors: Takao Kuroda; Masako Tada; Hiroshi Kubota; Hironobu Kimura; Shin-ya Hatano; Hirofumi Suemori; Norio Nakatsuji; Takashi Tada
Journal: Mol Cell Biol Date: 2005-03 Impact factor: 4.272

5. Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb.

Authors: W R MacLellan; A Garcia; H Oh; P Frenkel; M C Jordan; K P Roos; M D Schneider
Journal: Mol Cell Biol Date: 2005-03 Impact factor: 4.272

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.

1. Transcriptomics approach to investigate zebrafish heart regeneration.

2. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.

3. Physical interaction between TBX5 and MEF2C is required for early heart development.

4. Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression.

5. Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb.

6. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation.

7. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.

8. Dynamic single-cell imaging of direct reprogramming reveals an early specifying event.

9. Direct cell reprogramming is a stochastic process amenable to acceleration.

10. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

Review 1. Find and replace: editing human genome in pluripotent stem cells.

2. Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.

Review 3. Regulation of stem cell plasticity: mechanisms and relevance to tissue biology and cancer.

4. Rejuvenating liver and pancreas through cell transdifferentiation.

Review 5. Cellular reprogramming: a new technology frontier in pharmaceutical research.

6. Peptide amphiphile delivery of sonic hedgehog protein promotes neurite formation in penile projecting neurons.

Review 7. Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs.

Review 8. Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence.

9. Lineage Plasticity in Cancer Progression and Treatment.

10. Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium.