Literature DB >> 2125277

Synthesis and secretion of Alzheimer amyloid beta A4 precursor protein by stimulated human peripheral blood leucocytes.

U Mönning1, G König, R Prior, H Mechler, U Schreiter-Gasser, C L Masters, K Beyreuther.   

Abstract

Alzheimer amyloid precursor proteins (APP) are actively secreted by stimulated human peripheral mononuclear blood leucocytes (PMBLs). Induction of APP transcription, translation and secretion was observed with several T cell mitogens but was highest with phytohemagglutinin. The time course of induction is similar to that reported for IL-2 and IL-2 receptor. We suggest that APP may play an important role in the construction of the immunological network and the differentiation of T cells.

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Year:  1990        PMID： 2125277     DOI： 10.1016/0014-5793(90)80861-c

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter.

Authors:  P Pollwein; C L Masters; K Beyreuther
Journal:  Nucleic Acids Res       Date:  1992-01-11       Impact factor: 16.971

2.  USF binds to the APB alpha sequence in the promoter of the amyloid beta-protein precursor gene.

Authors:  A A Vostrov; W W Quitschke; F Vidal; A L Schwarzman; D Goldgaber
Journal:  Nucleic Acids Res       Date:  1995-07-25       Impact factor: 16.971

3.  Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-α: implications for autism.

Authors:  Antoinette R Bailey; Huayan Hou; Demian F Obregon; Jun Tian; Yuyan Zhu; Qiang Zou; William V Nikolic; Michael Bengtson; Takashi Mori; Tanya Murphy; Jun Tan
Journal:  FASEB J       Date:  2011-11-15       Impact factor: 5.191

4.  Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

Authors:  J D Buxbaum; M Oishi; H I Chen; R Pinkas-Kramarski; E A Jaffe; S E Gandy; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

5.  Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.

Authors:  A Tamaoka; R N Kalaria; I Lieberburg; D J Selkoe
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205

Review 6.  Microvascular pathology and vascular basement membrane components in Alzheimer's disease.

Authors:  L S Perlmutter
Journal:  Mol Neurobiol       Date:  1994 Aug-Dec       Impact factor: 5.590

Review 7.  Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.

Authors:  Judith Miklossy
Journal:  J Neuroinflammation       Date:  2011-08-04       Impact factor: 8.322

Review 8.  Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation.

Authors:  Judith Miklossy; Patrick L McGeer
Journal:  Aging (Albany NY)       Date:  2016-04       Impact factor: 5.682

9.  Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development.

Authors:  Karen Laky; Willem Annaert; B J Fowlkes
Journal:  Int Immunol       Date:  2009-08-26       Impact factor: 4.823

10.  Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity.

Authors:  Philipp Spitzer; Mateja Condic; Martin Herrmann; Timo Jan Oberstein; Marina Scharin-Mehlmann; Daniel F Gilbert; Oliver Friedrich; Teja Grömer; Johannes Kornhuber; Roland Lang; Juan Manuel Maler
Journal:  Sci Rep       Date:  2016-09-14       Impact factor: 4.379
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