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Literature DB >> 1359534

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

J D Buxbaum¹, M Oishi, H I Chen, R Pinkas-Kramarski, E A Jaffe, S E Gandy, P Greengard.

Abstract

Activation of protein kinase C by phorbol esters is known to accelerate the processing and secretion of the beta/A4 amyloid protein precursor. We have now examined various first messengers that increase protein kinase C activity of target cells for their ability to affect beta/A4 amyloid protein precursor metabolism. Acetylcholine and interleukin 1, which are altered in Alzheimer disease, were shown to increase processing of the beta/A4 amyloid protein precursor via the secretory cleavage pathway. Cholinergic agonists stimulated secretion in human glioma and neuroblastoma cells as well as in PC12 cells transfected with the M1 receptor, while interleukin 1 stimulated secretion in human endothelial and glioma cells.

Entities: Chemical Disease Species

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Year: 1992 PMID： 1359534 PMCID： PMC50280 DOI： 10.1073/pnas.89.21.10075

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

31 in total

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Authors: J D Buxbaum; S E Gandy; P Cicchetti; M E Ehrlich; A J Czernik; R P Fracasso; T V Ramabhadran; A J Unterbeck; P Greengard
Journal: Proc Natl Acad Sci U S A Date: 1990-08 Impact factor: 11.205

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Journal: Science Date: 1990-06-01 Impact factor: 47.728

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Journal: Nature Date: 1988-02-11 Impact factor: 49.962

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Journal: Biochem Biophys Res Commun Date: 1984-05-16 Impact factor: 3.575

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Authors: G L Caporaso; S E Gandy; J D Buxbaum; P Greengard
Journal: Proc Natl Acad Sci U S A Date: 1992-03-15 Impact factor: 11.205

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Journal: Nature Date: 1988-02-11 Impact factor: 49.962

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Authors: W S Griffin; L C Stanley; C Ling; L White; V MacLeod; L J Perrot; C L White; C Araoz
Journal: Proc Natl Acad Sci U S A Date: 1989-10 Impact factor: 11.205

133 in total

1. The M1 muscarinic agonist CI-1017 facilitates trace eyeblink conditioning in aging rabbits and increases the excitability of CA1 pyramidal neurons.

Authors: C Weiss; A R Preston; M M Oh; R D Schwarz; D Welty; J F Disterhoft
Journal: J Neurosci Date: 2000-01-15 Impact factor: 6.167

Review 2. The pervasiveness of interleukin-1 in alzheimer pathogenesis: a role for specific polymorphisms in disease risk.

Authors: W S Griffin; J A Nicoll; L M Grimaldi; J G Sheng; R E Mrak
Journal: Exp Gerontol Date: 2000-07 Impact factor: 4.032

Review 3. Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.

Authors: Gregory J Digby; Jana K Shirey; P Jeffrey Conn
Journal: Mol Biosyst Date: 2010-06-25

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Authors: J F Kelly; K Furukawa; S W Barger; M R Rengen; R J Mark; E M Blanc; G S Roth; M P Mattson
Journal: Proc Natl Acad Sci U S A Date: 1996-06-25 Impact factor: 11.205

5. Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets: a novel biomarker for acute coronary syndrome.

Authors: Shinobu Kitazume; Akiomi Yoshihisa; Takayoshi Yamaki; Masayoshi Oikawa; Yuriko Tachida; Kazuko Ogawa; Rie Imamaki; Yoshiaki Hagiwara; Noriaki Kinoshita; Yasuchika Takeishi; Katsutoshi Furukawa; Naoki Tomita; Hiroyuki Arai; Nobuhisa Iwata; Takaomi Saido; Naomasa Yamamoto; Naoyuki Taniguchi
Journal: J Biol Chem Date: 2012-10-02 Impact factor: 5.157