Literature DB >> 21248690

Large scale zebrafish-based in vivo small molecule screen.

Jijun Hao1, Charles H Williams, Morgan E Webb, Charles C Hong.   

Abstract

Given their small embryo size, rapid development, transparency, fecundity, and numerous molecular, morphological and physiological similarities to mammals, zebrafish has emerged as a powerful in vivo platform for phenotype-based drug screens and chemical genetic analysis. Here, we demonstrate a simple, practical method for large-scale screening of small molecules using zebrafish embryos.

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Year:  2010        PMID： 21248690      PMCID： PMC3159654          DOI： 10.3791/2243

Source DB:  PubMed          Journal:  J Vis Exp        ISSN： 1940-087X            Impact factor:   1.355


  10 in total

1.  Small molecule developmental screens reveal the logic and timing of vertebrate development.

Authors:  R T Peterson; B A Link; J E Dowling; S L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-21       Impact factor: 11.205

Review 2.  In vivo drug discovery in the zebrafish.

Authors:  Leonard I Zon; Randall T Peterson
Journal:  Nat Rev Drug Discov       Date:  2005-01       Impact factor: 84.694

3.  Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling.

Authors:  Charles C Hong; Quinn P Peterson; Ji-Young Hong; Randall T Peterson
Journal:  Curr Biol       Date:  2006-07-11       Impact factor: 10.834

4.  Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish.

Authors:  Peter E Bayliss; Kimberly L Bellavance; Geoffrey G Whitehead; Joshua M Abrams; Sandrine Aegerter; Heather S Robbins; Douglas B Cowan; Mark T Keating; Terence O'Reilly; Jeanette M Wood; Thomas M Roberts; Joanne Chan
Journal:  Nat Chem Biol       Date:  2006-03-26       Impact factor: 15.040

5.  High-throughput assay for small molecules that modulate zebrafish embryonic heart rate.

Authors:  C Geoffrey Burns; David J Milan; Eric J Grande; Wolfgang Rottbauer; Calum A MacRae; Mark C Fishman
Journal:  Nat Chem Biol       Date:  2005-09-18       Impact factor: 15.040

6.  Small molecules that delay S phase suppress a zebrafish bmyb mutant.

Authors:  Howard M Stern; Ryan D Murphey; Jennifer L Shepard; James F Amatruda; Christian T Straub; Kathleen L Pfaff; Gerhard Weber; John A Tallarico; Randall W King; Leonard I Zon
Journal:  Nat Chem Biol       Date:  2005-12       Impact factor: 15.040

7.  In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors.

Authors:  Jijun Hao; Joshua N Ho; Jana A Lewis; Kaleh A Karim; R Nathan Daniels; Patrick R Gentry; Corey R Hopkins; Craig W Lindsley; Charles C Hong
Journal:  ACS Chem Biol       Date:  2010-02-19       Impact factor: 5.100

8.  Drugs that induce repolarization abnormalities cause bradycardia in zebrafish.

Authors:  David J Milan; Travis A Peterson; Jeremy N Ruskin; Randall T Peterson; Calum A MacRae
Journal:  Circulation       Date:  2003-03-18       Impact factor: 29.690

9.  Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.

Authors:  Paul B Yu; Charles C Hong; Chetana Sachidanandan; Jodie L Babitt; Donna Y Deng; Stefan A Hoyng; Herbert Y Lin; Kenneth D Bloch; Randall T Peterson
Journal:  Nat Chem Biol       Date:  2007-11-18       Impact factor: 15.040

10.  Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation.

Authors:  Randall T Peterson; Stanley Y Shaw; Travis A Peterson; David J Milan; Tao P Zhong; Stuart L Schreiber; Calum A MacRae; Mark C Fishman
Journal:  Nat Biotechnol       Date:  2004-04-18       Impact factor: 54.908
  10 in total
  12 in total

1.  An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition.

Authors:  Charles H Williams; Jonathan E Hempel; Jijun Hao; Audrey Y Frist; Michelle M Williams; Jonathan T Fleming; Gary A Sulikowski; Michael K Cooper; Chin Chiang; Charles C Hong
Journal:  Cell Rep       Date:  2015-03-26       Impact factor: 9.423

2.  Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen.

Authors:  Jijun Hao; Ada Ao; Li Zhou; Clare K Murphy; Audrey Y Frist; Jessica J Keel; Curtis A Thorne; Kwangho Kim; Ethan Lee; Charles C Hong
Journal:  Cell Rep       Date:  2013-09-05       Impact factor: 9.423

3.  Zebrafish as an alternative model for hypoxic-ischemic brain damage.

Authors:  Xinge Yu; Yang V Li
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2011-04-20

Review 4.  LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.

Authors:  Philipp Gut; Sven Reischauer; Didier Y R Stainier; Rima Arnaout
Journal:  Physiol Rev       Date:  2017-07-01       Impact factor: 37.312

5.  Alternate glucocorticoid receptor ligand binding structures influence outcomes in an in vivo tissue regeneration model.

Authors:  Sumitra Sengupta; William H Bisson; Lijoy K Mathew; Siva K Kolluri; Robert L Tanguay
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2012-05-24       Impact factor: 3.228

Review 6.  Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition.

Authors:  Pawina Jiramongkolchai; Philip Owens; Charles C Hong
Journal:  Biochem Soc Trans       Date:  2016-08-15       Impact factor: 5.407

Review 7.  Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids.

Authors:  Francesco Abbate; Alessandro Maugeri; Rosaria Laurà; Maria Levanti; Michele Navarra; Santa Cirmi; Antonino Germanà
Journal:  Antioxidants (Basel)       Date:  2021-04-25

Review 8.  Multi-step usage of in vivo models during rational drug design and discovery.

Authors:  Charles H Williams; Charles C Hong
Journal:  Int J Mol Sci       Date:  2011-04-01       Impact factor: 5.923

9.  Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model.

Authors:  Corey S Martin; Akemi Moriyama; Leonard I Zon
Journal:  Genome Med       Date:  2011-12-29       Impact factor: 11.117

Review 10.  Zebrafish small molecule screens: Taking the phenotypic plunge.

Authors:  Charles H Williams; Charles C Hong
Journal:  Comput Struct Biotechnol J       Date:  2016-09-18       Impact factor: 7.271
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