Literature DB >> 21248146

Minireview: roles of the forkhead transcription factor FOXL2 in granulosa cell biology and pathology.

Margareta D Pisarska1, Gillian Barlow, Fang-Ting Kuo.   

Abstract

The forkhead transcription factor (FOXL2) is an essential transcription factor in the ovary. It is important in ovarian development and a key factor in female sex determination. In addition, FOXL2 plays a significant role in the postnatal ovary and follicle maintenance. The diverse transcriptional activities of FOXL2 are likely attributable to posttranslational modifications and binding to other key proteins involved in granulosa cell function. Mutations of FOXL2 lead to disorders of ovarian function ranging from premature follicle depletion and ovarian failure to unregulated granulosa cell proliferation leading to tumor formation. Thus, FOXL2 is a key regulator of granulosa cell function and a master transcription factor in these cells.

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Year:  2011        PMID： 21248146      PMCID： PMC3206711          DOI： 10.1210/en.2010-1041

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  118 in total

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