BACKGROUND/AIMS: The effects of chronic kidney disease (CKD) on the risk of death for patients with malignant disease are uncertain. The aim of this study was to determine the association between the presence of CKD and mortality in cancer patients. METHOD: We retrospectively reviewed the cases of 8,223 cancer patients with one or more serum creatinine measurements from January 1, 2000 to December 31, 2004. The key outcome was cancer-specific mortality within the follow-up period. The cumulative incidence rate for death from cancer was estimated using methods of competing risks survival analysis. Cox proportional-hazards regression with the use of Fine and Gray's proportional-hazards model were evaluated in multiple analyses. RESULTS: CKD was associated with an increased risk of death in cancer patients. The adjusted hazard ratios were 1.12 for patients with an estimated glomerular filtration rate (eGFR) of 30-59 ml/min/1.73 m(2) (95% confidence interval 1.01-1.26, p = 0.04) and 1.75 for patients with an eGFR <30 ml/min/1.73 m(2) (95% confidence interval 1.32-2.32, p < 0.001). CONCLUSIONS: CKD should be considered a risk factor for survival among patients with cancer.
BACKGROUND/AIMS: The effects of chronic kidney disease (CKD) on the risk of death for patients with malignant disease are uncertain. The aim of this study was to determine the association between the presence of CKD and mortality in cancerpatients. METHOD: We retrospectively reviewed the cases of 8,223 cancerpatients with one or more serum creatinine measurements from January 1, 2000 to December 31, 2004. The key outcome was cancer-specific mortality within the follow-up period. The cumulative incidence rate for death from cancer was estimated using methods of competing risks survival analysis. Cox proportional-hazards regression with the use of Fine and Gray's proportional-hazards model were evaluated in multiple analyses. RESULTS:CKD was associated with an increased risk of death in cancerpatients. The adjusted hazard ratios were 1.12 for patients with an estimated glomerular filtration rate (eGFR) of 30-59 ml/min/1.73 m(2) (95% confidence interval 1.01-1.26, p = 0.04) and 1.75 for patients with an eGFR <30 ml/min/1.73 m(2) (95% confidence interval 1.32-2.32, p < 0.001). CONCLUSIONS:CKD should be considered a risk factor for survival among patients with cancer.
Authors: K Boehm; M Duckheim; L Mizera; P Groga-Bada; N Malek; F Kreth; M Gawaz; C S Zuern; C Eick Journal: Support Care Cancer Date: 2018-04-12 Impact factor: 3.603
Authors: Carolin Grafe; Sabine Semrau; Alexander Hein; Matthias W Beckmann; Andreas Mackensen; Frank Dörje; Martin F Fromm Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2018-01-02 Impact factor: 3.000
Authors: Jason N Barreto; Kristen T Peterson; Erin F Barreto; Kristin C Mara; Ross A Dierkhising; Nelson Leung; Thomas E Witzig; Carrie A Thompson Journal: Support Care Cancer Date: 2021-03-04 Impact factor: 3.603
Authors: Arthur Sillah; Nathaniel F Watson; Ulrike Peters; Mary L Biggs; F Javier Nieto; Christopher I Li; David Gozal; Timothy Thornton; Sonnah Barrie; Amanda I Phipps Journal: Cancer Epidemiol Date: 2021-11-17 Impact factor: 2.984