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Literature DB >> 2124255

Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: implication for their cytotoxic role in vivo.

M Nakata¹, M J Smyth, Y Norihisa, A Kawasaki, Y Shinkai, K Okumura, H Yagita.

Abstract

The cytotoxic activity and pore-forming protein (PFP) expression of human peripheral blood (PB) gamma/delta T cells were examined. Fresh gamma/delta T cells isolated from PB lymphocytes by fluorescence-activated cell sorting exhibited a substantial natural killer-like cytotoxic activity against K562 target cells and had a high cytotoxic potential triggered by anti-CD3 monoclonal antibody (mAb) against P815 target cells bearing Fc gamma R. Immunocytochemical staining with an anti-PFP mAb revealed that virtually all PB gamma/delta T cells are granular lymphocytes with abundant PFP in their cytoplasmic granules. Constitutive expression of PFP in PB gamma/delta T cells was also demonstrated by Northern blot analysis. These observations support the proposed role of gamma/delta T cells in cytolytic immune surveillance in vivo.

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Year: 1990 PMID： 2124255 PMCID： PMC2188778 DOI： 10.1084/jem.172.6.1877

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

16 in total

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Authors: F Triebel; T Hercend
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Authors: D H Raulet
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Journal: Proc Natl Acad Sci U S A Date: 1989-03 Impact factor: 11.205

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Authors: F Faure; S Jitsukawa; F Triebel; T Hercend
Journal: J Immunol Date: 1988-03-01 Impact factor: 5.422

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Journal: J Immunol Date: 1989-10-15 Impact factor: 5.422

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Authors: A Kawasaki; Y Shinkai; Y Kuwana; A Furuya; Y Iigo; N Hanai; S Itoh; H Yagita; K Okumura
Journal: Int Immunol Date: 1990 Impact factor: 4.823

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Journal: Immunogenetics Date: 1989 Impact factor: 2.846

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Journal: Eur J Immunol Date: 1989-07 Impact factor: 5.532

10. Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function.

Authors: T Goodman; L Lefrancois
Journal: J Exp Med Date: 1989-11-01 Impact factor: 14.307

23 in total

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2. Histamine modulates γδ-T lymphocyte migration and cytotoxicity, via Gi and Gs protein-coupled signalling pathways.

Authors: K Truta-Feles; M Lagadari; K Lehmann; L Berod; S Cubillos; S Piehler; Y Herouy; D Barz; T Kamradt; Aa Maghazachi; J Norgauer
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3. Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states.

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4. Expression of cytolytic mediators by synovial fluid lymphocytes in rheumatoid arthritis.

Authors: L H Young; S V Joag; P Y Lin; S F Luo; L M Zheng; C C Liu; J D Young
Journal: Am J Pathol Date: 1992-05 Impact factor: 4.307

5. The protective role of T-cell receptor Vgamma1+ T cells in primary infection with Listeria monocytogenes.

Authors: T Nakamura; G Matsuzaki; K Nomoto
Journal: Immunology Date: 1999-01 Impact factor: 7.397

6. CDR3δ -grafted γ9δ2T cells mediate effective antitumor reactivity.

Authors: Hui Zhao; Xueyan Xi; Lianxian Cui; Wei He
Journal: Cell Mol Immunol Date: 2011-09-12 Impact factor: 11.530

7. Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood.

Authors: J A Kummer; A M Kamp; T M Tadema; W Vos; C J Meijer; C E Hack
Journal: Clin Exp Immunol Date: 1995-04 Impact factor: 4.330

8. Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease.

Authors: Z Wu; E R Podack; J M McKenzie; K J Olsen; M Zakarija
Journal: Clin Exp Immunol Date: 1994-12 Impact factor: 4.330

9. Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody.

Authors: A Hameed; K J Olsen; L Cheng; W M Fox; R H Hruban; E R Podack
Journal: Am J Pathol Date: 1992-05 Impact factor: 4.307

10. Two unique human leukemic T-cell lines endowed with a stable cytotoxic function and a different spectrum of target reactivity analysis and modulation of their lytic mechanisms.

Authors: A Cesano; D Santoli
Journal: In Vitro Cell Dev Biol Date: 1992 Sep-Oct