Fish oil and vascular disease.

Dietary n-3 fatty acids have potent biologic effects on cells of the blood and the vasculature. Many of these actions could ultimately prove medically useful, with potential therapeutic impact on atherogenesis, thrombosis, or vascular reactivity. Although a few clinical trials of fish oil have been reported in humans (for example, prevention of reocclusion after coronary angioplasty), results have not yet been definitive. Until additional information is available, the use of fish-oil supplements for treatment or prophylaxis of cardiovascular disease is not warranted.