| Literature DB >> 21236563 |
Hannelien Verbeke1, Sofie Struyf, Nele Berghmans, Els Van Coillie, Ghislain Opdenakker, Catherine Uyttenhove, Jacques Van Snick, Jo Van Damme.
Abstract
The chemokine granulocyte chemotactic protein (GCP)-2/CXCL6 promotes tumor growth as angiogenesis inducer and neutrophil chemoattractant. The neutralizing capacity and specificity of monoclonal mouse anti-murine (mu)GCP-2/CXCL6 antibodies were evidenced by granulocyte chemotaxis and signaling assays. The half-life of the non-antigenic antibody in the blood circulation was approximately 15 days. The titers remained constant upon weekly injection. Tumor growth and lymphogenic metastases of human melanoma over-expressing muGCP-2 were reduced in mice treated with anti-muGCP-2. Moreover, the drop in muGCP-2 antibody titer correlated with the melanoma tumor size. Taken together, we show that functional blocking of GCP-2 inhibits tumor growth and metastases.Entities:
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Year: 2011 PMID： 21236563 DOI： 10.1016/j.canlet.2010.12.013
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679