Literature DB >> 2123100

Effect of thyroid hormone on hepatic cholesterol 7 alpha hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein A-I mRNA levels in hypophysectomized rats.

G C Ness1, L C Pendleton, Y C Li, J Y Chiang.   

Abstract

The effects of thyroid hormone on cholesterol 7 alpha hydroxylase, LDL receptor, HMG-CoA reductase, apo A-I and farnesyl pyrophosphate synthetase hepatic mRNA levels were investigated in hypophysectomized rats. Of these mRNAs cholesterol 7 alpha hydroxylase responded the most rapidly and required the lowest dose of T3. Maximal mRNA levels were reached one hr after T3 administration and required 10 micrograms/100g of body weight. These results suggest that the hypocholesterolemic effect of thyroid hormone may be mediated by a primary effect on cholesterol 7 alpha hydroxylase gene expression.

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Year:  1990        PMID： 2123100     DOI： 10.1016/0006-291x(90)91568-d

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  25 in total

Review 1.  Thyroid hormones and thyroid hormone receptors: effects of thyromimetics on reverse cholesterol transport.

Authors:  Matteo Pedrelli; Camilla Pramfalk; Paolo Parini
Journal:  World J Gastroenterol       Date:  2010-12-21       Impact factor: 5.742

Review 2.  Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.

Authors:  Timothy F Osborne; Peter J Espenshade
Journal:  Genes Dev       Date:  2009-11-15       Impact factor: 11.361

Review 3.  Thyroid hormone analogues and derivatives: Actions in fatty liver.

Authors:  Maria Coppola; Daniela Glinni; Maria Moreno; Federica Cioffi; Elena Silvestri; Fernando Goglia
Journal:  World J Hepatol       Date:  2014-03-27

4.  Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice.

Authors:  Lisen Johansson; Mats Rudling; Thomas S Scanlan; Thomas Lundåsen; Paul Webb; John Baxter; Bo Angelin; Paolo Parini
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-08       Impact factor: 11.205

5.  The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo.

Authors:  Seo-Hee You; Xiaohui Liao; Roy E Weiss; Mitchell A Lazar
Journal:  Mol Endocrinol       Date:  2010-04-28

Review 6.  Treatment of familial hypercholesterolemia: is there a need beyond statin therapy?

Authors:  Anna Raper; Daniel M Kolansky; Marina Cuchel
Journal:  Curr Atheroscler Rep       Date:  2012-02       Impact factor: 5.113

7.  Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat.

Authors:  M Rudling; P Parini; B Angelin
Journal:  J Clin Invest       Date:  1997-05-01       Impact factor: 14.808

8.  DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism.

Authors:  Martina Zikova; Alicia Corlett; Zdenka Bendova; Petr Pajer; Petr Bartunek
Journal:  Mol Endocrinol       Date:  2009-01-29

9.  Decreased expression of cholesterol 7alpha-hydroxylase and altered bile acid metabolism in Apobec-1-/- mice lead to increased gallstone susceptibility.

Authors:  Yan Xie; Valerie Blanc; Thomas A Kerr; Susan Kennedy; Jianyang Luo; Elizabeth P Newberry; Nicholas O Davidson
Journal:  J Biol Chem       Date:  2009-04-22       Impact factor: 5.157

10.  Regulation of cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase mRNA levels by L-tri-iodothyronine.

Authors:  T Royo; D Haro; F G Hegardt
Journal:  Biochem J       Date:  1993-01-15       Impact factor: 3.857
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