OBJECTIVE: Stress, either physical or psychological, can modulate immune function. However, the mechanisms associated with stress-induced immune suppression remain to be elucidated. β-Arrestin 2 serves as adaptor, scaffold, and/or signal transducer. The role of β-arrestin 2 in stress-induced immune suppression is not known yet. METHODS/ RESULTS: Here, we demonstrate that β-arrestin 2 deficiency in mice increases the sensitivity to the chronic stress-induced reduction in the number of splenocytes. Interestingly, the stress-induced suppression of T helper-type (Th) 1 cytokines and the increased production of Th2 cytokines were greatly enhanced in β-arrestin 2-deficient mice compared with wild-type mice. Moreover, inhibition of PI3K in β-arrestin 2-deficient mice exerts an additive effect on the stress-induced reduction in the number of splenocytes. CONCLUSION: Our study demonstrates that a deficiency in β-arrestin 2 augments stress-induced immune suppression. 2011 S. Karger AG, Basel.
OBJECTIVE: Stress, either physical or psychological, can modulate immune function. However, the mechanisms associated with stress-induced immune suppression remain to be elucidated. β-Arrestin 2 serves as adaptor, scaffold, and/or signal transducer. The role of β-arrestin 2 in stress-induced immune suppression is not known yet. METHODS/ RESULTS: Here, we demonstrate that β-arrestin 2 deficiency in mice increases the sensitivity to the chronic stress-induced reduction in the number of splenocytes. Interestingly, the stress-induced suppression of T helper-type (Th) 1 cytokines and the increased production of Th2 cytokines were greatly enhanced in β-arrestin 2-deficient mice compared with wild-type mice. Moreover, inhibition of PI3K in β-arrestin 2-deficient mice exerts an additive effect on the stress-induced reduction in the number of splenocytes. CONCLUSION: Our study demonstrates that a deficiency in β-arrestin 2 augments stress-induced immune suppression. 2011 S. Karger AG, Basel.
Authors: Christopher D Nelson; Stephen J Perry; Debra S Regier; Stephen M Prescott; Matthew K Topham; Robert J Lefkowitz Journal: Science Date: 2007-02-02 Impact factor: 47.728
Authors: Victor Gabriel Clatici; Daniel Racoceanu; Claude Dalle; Cristiana Voicu; Lucia Tomas-Aragones; Servando E Marron; Uwe Wollina; Simona Fica Journal: Maedica (Bucur) Date: 2017-09